Protein Summary
Has an important role in epithelial desmosome-mediated cell-cell adhesion. The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]
- ENST00000353706
- ENSP00000331368
- ENSG00000166401
- ENST00000397985
- ENSP00000381072
- ENST00000397988
- ENSP00000381075
- ENST00000542677
- ENSP00000438328
- PI8
- PI8
- CAP2
- PI-8
- PSS5
- C18orf53
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.81 | ||
tissue sample | 0.68 | ||
cell type or tissue | 0.62 | ||
interacting protein | 0.62 | ||
microRNA | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.05 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 250 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.05 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 250 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0