CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform
Protein Summary
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000265641
- ENSP00000265641
- ENSG00000110090
- ENST00000376618
- ENSP00000365803
- ENST00000539743
- ENSP00000446108
- ENST00000540367
- ENSP00000439084
- CPT1
- CPT1
- CPT1-L
- L-CPT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
metabolite | 1 | ||
interacting protein | 0.99 | ||
biological process | 0.95 | ||
disease perturbation | 0.93 | ||
PubMedID | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.6 (req: < 5)
Gene RIFs: 109 (req: <= 3)
Antibodies: 397 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 464.6 (req: >= 5)
Gene RIFs: 109 (req: > 3)
Antibodies: 397 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 467
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0