Property Summary

NCBI Gene PubMed Count 72
PubMed Score 203.77
PubTator Score 99.93

Knowledge Summary

Patent (25,376)



Accession P50406 Q13640 Q5TGZ1 5-HT-6
Symbols 5-HT6


PANTHER Protein Class (2)

  Ortholog (7)

Species Source
Chimp OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Xenopus OMA EggNOG

  TechDev Info (1)

MLP Assay (3)

AID Type Active / Inconclusive / Inactive Description
434974 screening 0 / 0 / 0 Late-stage radioligand binding assay to identify inhibitors of NADPH oxidase 1 (NOX1): PDSP screen
504381 other 0 / 0 / 0 Late-stage radioligand binding assay to identify inhibitors of NADPH oxidase 1 (NOX1): PDSP screen Set 2
652083 other 0 / 0 / 0 Late-stage results from the probe development effort to identify antagonists of OPRK1: CEREP radiometric-based biochemical counterscreen panel assay

Gene RIF (64)

26449188 Serotonin 6 receptor has a role in Alzheimer's disease and depression
25034463 that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment
24850589 Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD).
23844689 [review] Controlling the activity of 5-HTR6 receptors seems to provide benefits by alleviating cognitive impairments.
23542166 Data indicate that hydrogen-bond formation of a methoxy or hydroxy group is not important for binding at the 5-HT6 receptor.
23027611 These observations suggest that recruitment of mTOR by prefrontal 5-HT(6) receptors contributes to the perturbed cognition in schizophrenia, offering new vistas for its therapeutic control.
22833193 When expressed in pyramidal neuron progenitors, serotonin receptor 5-HT6 transgene decreases the migration speed of cortical pyramidal neurons, thereby affecting a fundamental step in the assembly of neural circuits.
22745941 results indicate that tagging SNPs in HTR6 may not play a role in the pathophysiology of schizophrenia.
22278721 present findings showed the presence of a higher density of 5-HT(6) receptors, as labeled by [(125)I]SB-258585, in striatum than in hippocampus and prefrontal cortex, and specifically within the neuronal body
21728060 There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6.

AA Sequence

FNIDPAEPELRPHPLGIPTN                                                      421 - 440

Text Mined References (73)

PMID Year Title
26449188 2015 Serotonin 6 receptor controls Alzheimer's disease and depression.
25034463 2015 5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy.
24850589 2014 Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease.
23844689 2013 Improving the treatment of schizophrenia: role of 5-HT receptors in modulating cognitive and extrapyramidal motor functions.
23542166 2013 Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
23027611 2012 5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.
22833193 2011 Excess of serotonin affects neocortical pyramidal neuron migration.
22745941 2012 Serotonin 6 receptor gene and schizophrenia: case-control study and meta-analysis.
22278721 2012 Distribution of serotonin receptor of type 6 (5-HT?) in human brain post-mortem. A pharmacology, autoradiography and immunohistochemistry study.
21829518 2011 Serotonin receptor expression in human prefrontal cortex: balancing excitation and inhibition across postnatal development.