Tbio RBP2 Retinol-binding protein 2

Protein Summary

Description

Intracellular transport of retinol. This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P50120
• A8K7G3
• Q6ISQ9
• Q6ISS7

Gene Name

• RBP2

Ensembl ID

• ENST00000232217
• ENSP00000232217
• ENSG00000114113

Symbol

• CRBP2
• CRBP2
• RBPC2
• CRBPII
• CRABP-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.59
protein domain	0.58
disease	0.51
cell type or tissue	0.48
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.3   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 237   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.3   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0