Property Summary

NCBI Gene PubMed Count 159
PubMed Score 600.46
PubTator Score 470.16

Knowledge Summary


No data available


  Disease Sources (5)

Disease Target Count P-value
non-small cell lung cancer 2798 4.37839511991165E-14
Breast cancer 3099 1.28325607172701E-12
lung adenocarcinoma 2714 1.06651566138322E-9
malignant mesothelioma 3163 1.53579857475189E-7
breast carcinoma 1614 5.48876406626949E-6
ovarian cancer 8492 7.1196717734631E-6
psoriasis 6685 1.04277185723144E-5
tuberculosis and treatment for 3 months 327 7.2064873633651E-5
adrenocortical carcinoma 1427 1.44670456594253E-4
ductal carcinoma in situ 1745 1.8401657254649E-4
pancreatic cancer 2300 2.59656065407711E-4
pancreatic carcinoma 567 2.59656065407712E-4
pituitary cancer 1972 5.49213169568581E-4
head and neck cancer 270 5.77054078622498E-4
Atopic dermatitis 944 0.00209695742406428
group 4 medulloblastoma 1875 0.00212228314919103
aldosterone-producing adenoma 664 0.00215639975894342
chronic rhinosinusitis 512 0.00263908315250076
fibroadenoma 557 0.0028808117386913
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00517823512001102
invasive ductal carcinoma 2950 0.00541537357454355
subependymal giant cell astrocytoma 2287 0.00550132716734094
gastric cancer 436 0.0105237836542581
intraductal papillary-mucinous adenoma (IPMA) 2956 0.01137481785117
Down syndrome 548 0.0136923871701065
Common variable immunodeficiency 98 0.0139060045804801
non primary Sjogren syndrome sicca 840 0.0156564617802023
osteosarcoma 7933 0.0307672659523635
active ulcerative colitis 477 0.0479869350822068
ependymoma 2514 0.0485789777142798
Disease Target Count Z-score Confidence
IMAGe syndrome 6 5.937 3.0



Accession P49918
Symbols BWS


  Ortholog (4)

Species Source
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Cow OMA EggNOG Inparanoid
Xenopus EggNOG Inparanoid

 GO Component (2)

Gene RIF (138)

26606000 Jab1/Csn5 expression with concurrent low p57 expression associated with poor overall survival in hepatocellular carcinoma
26362858 These results indicate that the inhibitory effect of rapamycin may be due mainly to increased p14, p15, and p57 expression via promoter demethylation and decreased mTOR and p70S6K expression in ALL cell lines.
26271467 Our data indicated that reduced cytoplasmic p57 expression is associated with hepatocellular carcinoma invasion.
26161420 Polymer-based immunohistochemical staining of p57(kip2) (paternally imprinted gene, expressed from maternal allele) is a very effective method that can be used to differentiate androgenetic complete mole from partial mole and hydropic abortion.
26091021 Using human placental samples, we show that the expression of the imprinted gene CDKN1C associates with birth weight
26077438 CDKN1C sequencing should be performed for BWS patients presenting with abdominal wall defects or cleft palate without 11p15 methylation defects or body asymmetry, or in familial cases of BWS.
25960208 downregulation of CDKN1 by siRNA blocked the activity of miR-25 on promoting glioma cell proliferation.
25588980 Up-regulation of miR-199a-5p in ADPKD tissues might promote cell proliferation through suppressing CDKN1C
25427884 Data show the presence of maternally derived extra copies of the distal chromosome 11p involving the wild-type cyclin-dependent kinase inhibitor 1C protein (CDKN1C).
25339094 Lefty1 could regulates the cell cycle via modulating the expressions of P57 and cyclin D1 and then inhibit the decidualization in vitro.

AA Sequence

RSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR                                      281 - 316

Text Mined References (157)

PMID Year Title
26606000 2016 Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis.
26362858 2015 Rapamycin restores p14, p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute lymphoblastic leukemia cells.
26271467 2015 The role of cytoplasmic p57 in invasion of hepatocellular carcinoma.
26161420 2015 Clinical Usefulness of Immunohistochemical Staining of p57 kip2 for the Differential Diagnosis of Complete Mole.
26091021 2015 Placental 5-methylcytosine and 5-hydroxymethylcytosine patterns associate with size at birth.
26077438 2015 Mutations of the Imprinted CDKN1C Gene as a Cause of the Overgrowth Beckwith-Wiedemann Syndrome: Clinical Spectrum and Functional Characterization.
25960208 2015 miR-25 promotes glioma cell proliferation by targeting CDKN1C.
25588980 2015 Inhibition of MiR-199a-5p reduced cell proliferation in autosomal dominant polycystic kidney disease through targeting CDKN1C.
25427884 2015 Silver-Russell syndrome without body asymmetry in three patients with duplications of maternally derived chromosome 11p15 involving CDKN1C.
25339094 2014 Lefty inhibits in vitro decidualization by regulating P57 and cyclin D1 expressions.