Property Summary

NCBI Gene PubMed Count 82
PubMed Score 315.17
PubTator Score 106.12

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 1.14886837157495E-25
lung carcinoma 2844 1.20585239032889E-10
Duchenne muscular dystrophy 602 9.07264867781954E-8
lung cancer 4473 2.05853441258398E-6
Breast cancer 3099 4.32183576125989E-6
lung adenocarcinoma 2714 9.02823407838301E-6
pituitary cancer 1972 3.11306127901455E-5
ovarian cancer 8492 1.40214840195689E-4
atypical teratoid/rhabdoid tumor 1095 3.63929200093694E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 4.02956144445204E-4
Multiple myeloma 1328 4.34987303184868E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00109350757868298
osteosarcoma 7933 0.00174866411427899
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00182530384830324
group 3 medulloblastoma 2254 0.00214348059204622
Atopic dermatitis 944 0.00239860831432438
posterior fossa group B ependymoma 1530 0.0040144003798181
non diabetic and post-ischemic heart failure 200 0.00473552038693441
Down syndrome 548 0.00511921600360826
medulloblastoma, large-cell 6234 0.00772389348650378
cystic fibrosis 1670 0.00811228846170224
invasive ductal carcinoma 2950 0.00884158538754365
colon cancer 1475 0.0164090898588852
active ulcerative colitis 477 0.0209773594728957
chronic rhinosinusitis 512 0.0377457303718919
gastric carcinoma 832 0.0421139444282911
Disease Target Count Z-score Confidence
Cancer 2346 3.28 1.6



Accession P49908 Q6PD59 Q6PI43 Q6PI87 Q6PJF9 SeP
Symbols SeP


  Ortholog (2)

Species Source
Mouse OMA EggNOG Inparanoid
Platypus OMA EggNOG

 GO Function (1)

Gene RIF (65)

26675765 women who carry the SEPP1 rs3877899 A allele are better able to maintain selenium status during pregnancy, and their GPx3 activity increases more with supplementation, which suggests better protection from low selenium status.
26514640 Selenoprotein P concentrations are not elevated in women with gestational diabetes mellitus but are associated with BMI and HDL cholesterol.
26399395 Studied gene-specific regulation of hepatic selenoprotein expression by interleukin-6; by testing human hepatocytes in culture, found IL-6 reduced the concentrations of SePP mRNA and secreted SePP in a dose-dependent manner.
26348725 Impaired renal function is positively correlated with serum concentrations of SePP.
25395084 this study provide preliminary genetic evidence that the SEPP1 functional variants contribute to the AAA risk.
24914767 These results demonstrated that SelP interacts with tubulin, alpha 1a (TUBA1A).
24708917 Data suggest that plasma SEPP1 level can be up-regulated by dietary factors; here, significantly higher plasma SEPP1 is observed in women at risk of pre-eclampsia treated with dietary supplement of selenium-enriched yeast started in first trimester.
24638201 Elevated SeP concentrations are independently associated with a reduced risk of MetS in children
24563517 SEPP1 rs7579 was found to be associated with lower risk of advanced prostate cancer.
24437729 The histidine-rich domain of selenoprotein P is capable of binding Cu ions in both oxidation states of Cu(+) and Cu(2+) with high affinity and of modulating Cu(+) and Cu(2+)-mediated ABETA aggregation, reactive oxygen species production, neurotoxicity.

AA Sequence

AUQISQQLIPTEASASURUKNQAKKUEUPSN                                           351 - 381

Text Mined References (86)

PMID Year Title
26675765 2016 Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.
26514640 2015 Selenoprotein P is not elevated in gestational diabetes mellitus.
26399395 2015 Gene-specific regulation of hepatic selenoprotein expression by interleukin-6.
26348725 2015 Chronic Kidney Disease Distinctly Affects Relationship Between Selenoprotein P Status and Serum Thyroid Hormone Parameters.
25395084 2014 SEPP1 gene variants and abdominal aortic aneurysm: gene association in relation to metabolic risk factors and peripheral arterial disease coexistence.
24914767 2014 Direct interaction between selenoprotein P and tubulin.
24708917 2014 Effect of selenium on markers of risk of pre-eclampsia in UK pregnant women: a randomised, controlled pilot trial.
24638201 2014 Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children.
24563517 2014 Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer.
24437729 2014 Inhibitory effect of selenoprotein P on Cu(+)/Cu(2+)-induced A?42 aggregation and toxicity.