Property Summary

NCBI Gene PubMed Count 111
PubMed Score 52.32
PubTator Score 143.91

Knowledge Summary

Patent (6,631)



Accession P49840 O14959 GSK-3 alpha




  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Pig OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA Inparanoid

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (9)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448
2650 screening 318 / 1 / 315189 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha
2709 summary 0 / 0 / 0 Summary of Broad Institute MLPCN Glycogen Synthase Kinase-3 alpha Project
463203 confirmatory 769 / 18 / 1565 Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha
588361 confirmatory 15 / 1 / 0 Inhibition of Human GSK-3 alpha Activity Measured in Biochemical System Using Microfluidics - 2063-06_Inhibitor_Dose_DryPowder_Activity
588434 confirmatory 25 / 1 / 0 Inhibition of Human GSK-3 alpha Activity Measured in Biochemical System Using Microfluidics - 2063-06_Inhibitor_Dose_DryPowder_Activity_Set2
588725 other 0 / 0 / 1 Late stage counterscreen results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): Radioactivity-based biochemical assay to identify modulators of a panel of 48 kinases
623978 confirmatory 18 / 3 / 3 Inhibition of Human GSK3 alpha Activity Measured in Biochemical System Using Microfluidics - 2046-11_Inhibitor_Dose_DryPowder_Activity_Set2
652206 other 0 / 0 / 0 ML-187 activity in a kinase panel for Extended probe characterization for beta-cell apoptosis Measured in Biochemical System

Gene RIF (78)

27049759 demonstrated that GSK-3alpha is regulated by CREB in lung cancer and is required for the cell viability. These findings implicate CREB-GSK-3alpha axis as a novel therapeutic target for lung cancer treatment
26766591 reveals that GSK-3alpha- and GSK-3beta-regulated pathways can be responsible for stepwise transition to myelodysplastic syndromes and subsequent acute myeloid leukemia
26393419 GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction.
25935310 CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation.
25561726 Data indicate that autophagy inhibition promotes glycogen synthase kinase-(GSK3) inhibition-induced apoptosis.
25550525 glycogen synthase kinase 3 alpha and beta activity is increased in foetal membranes after term and preterm labour
25486534 Elevated GSK3 protein kinase activity is associated with non-small cell lung carcinoma
25187516 PtpA has a role in promoting anti-apoptotic activity of protein-dependent dephosphorylation of host GSK3alpha
25183803 ER stress-PERK-GSK3alpha/beta signaling promotes proatherogenic macrophage lipid accumulation
24984063 GSK3A is redundant with GSK3B in regulating drug-resistance and chemotherapy-induced necroptosis

AA Sequence


Text Mined References (123)

PMID Year Title
27049759 2016 GSK-3? Is a Novel Target of CREB and CREB-GSK-3? Signaling Participates in Cell Viability in Lung Cancer.
26766591 2016 GSK3 Deficiencies in Hematopoietic Stem Cells Initiate Pre-neoplastic State that Is Predictive of Clinical Outcomes of Human Acute Leukemia.
26393419 2015 A novel GSK3-regulated APC:Axin interaction regulates Wnt signaling by driving a catalytic cycle of efficient ?catenin destruction.
25935310 2015 Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.
25561726 2015 Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells.
25550525 2015 A novel role for GSK3 in the regulation of the processes of human labour.
25486534 2014 Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation.
25187516 2014 Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3?.
25183803 2014 Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3?/? regulate foam cell formation.
24984063 2014 GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis.