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Tbio
TSC2
Tuberin

Protein Summary
Description
In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059). May also play a role in microtubule-mediated protein transport (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity). Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219476
  • ENSP00000219476
  • ENSG00000103197
  • ENST00000350773
  • ENSP00000344383
  • ENST00000382538
  • ENSP00000371978
  • ENST00000401874
  • ENSP00000384468
  • ENST00000439673
  • ENSP00000399232
  • ENST00000642936
  • ENSP00000494514
  • ENST00000644043
  • ENSP00000496262

Symbol
  • TSC4
  • LAM
  • TSC4
  • PPP1R160
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.99
biological term
0.98
disease perturbation
0.9
kinase
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1830.65   (req: < 5)
Gene RIFs: 340   (req: <= 3)
Antibodies: 1854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1830.65   (req: >= 5)
Gene RIFs: 340   (req: > 3)
Antibodies: 1854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0