Tchem PSEN2 Presenilin-2

Protein Summary

Description

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P49810
• A8K8D4
• B1AP21
• Q96P32
• PS-2

Gene Name

• PSEN2

Ensembl ID

• ENST00000366783
• ENSP00000355747
• ENSG00000143801
• ENST00000422240
• ENSP00000403737

Symbol

• AD4
• PS2
• PSNL2
• STM2
• AD4
• PS2
• AD3L
• STM2
• CMD1V

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
cellular component	0.83
transcription factor binding site profile	0.77
hub protein	0.71
kinase perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Presenilin-2

Protein / Hydrolase / Protease / Aspartic Protease / Presenilin-2

Protein / Calcium-binding Protein / Presenilin-2

DTO Classes

Protein / Enzyme / Protease / Aspartic Protease / Presenilin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 939.35   (req: < 5)

Gene RIFs: 158   (req: <= 3)

Antibodies: 404   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 939.35   (req: >= 5)

Gene RIFs: 158   (req: > 3)

Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0