Property Summary

NCBI Gene PubMed Count 37
PubMed Score 49.54
PubTator Score 30.17

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 1.54344820896427E-40
posterior fossa group A ependymoma 1511 2.71710185377217E-17
oligodendroglioma 2849 4.35386875550895E-12
atypical teratoid / rhabdoid tumor 4369 1.55626102472282E-11
pediatric high grade glioma 2712 7.44476403349247E-8
pilocytic astrocytoma 3086 7.49695778811477E-8
malignant mesothelioma 3163 2.8287663064167E-7
medulloblastoma, large-cell 6234 7.65812193229801E-7
cystic fibrosis 1670 9.13889433811819E-7
glioblastoma 5572 1.17583402130153E-6
sonic hedgehog group medulloblastoma 1482 2.76387120272216E-5
pituitary cancer 1972 2.34411285211491E-4
astrocytic glioma 2241 0.00135334046130307
primitive neuroectodermal tumor 3031 0.00188947101813651
non primary Sjogren syndrome sicca 840 0.0326267993744003
Pick disease 1893 0.0352330031345346
severe Alzheimer's disease 49 0.0377300065461099
Parkinson's disease 364 0.0405320827574525
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0461419005282954
subependymal giant cell astrocytoma 2287 0.0493870361406826
Disease Target Count Z-score Confidence
Leiomyomatosis 5 4.023 2.0
Night Blindness 39 3.928 2.0
Uterine fibroid 29 3.58 1.8

Expression

Synonym

Gene

PANTHER Protein Class (2)

PDB

2A72   2D9J  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Anole lizard OMA Inparanoid

MLP Assay (5)

AID Type Active / Inconclusive / Inactive Description
1439 screening 770 / 33746 / 183961 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
1837 screening 129 / 0 / 1529 Single point concentration, multiplexed high-throughput screen for confirmation of small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
1871 confirmatory 30 / 0 / 155 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
2296 confirmatory 14 / 0 / 22 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao for SAR Compounds
2826 confirmatory 0 / 0 / 5 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao with additional round of SAR compounds.

Gene RIF (18)

PMID Text
26895961 R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.
26113603 Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval
23857581 the GAP activity of RGS9-2 showed a strong receptor preference for D2R over MOR. Finally, RGS7 displayed an four times greater GAP activity relative to RGS9-2.
23054467 New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy.
21343290 Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627871 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19626040 common variation within the RGS7 locus may be involved in multiple sclerosis susceptibility.
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AA Sequence

MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNL      1 - 70
TIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNK     71 - 140
ARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTT    141 - 210
EVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVA    211 - 280
DSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKF    281 - 350
LESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFE    351 - 420
DAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRA    421 - 490
STNLL                                                                     491 - 495
//

Text Mined References (40)

PMID Year Title
26895961 2016 Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by G?o and R7-binding Protein.
26113603 2015 Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval.
25199915 2015 GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
25102180 2014 Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
23857581 2013 Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23054467 2013 New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy.
21343290 2011 Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20627871 2010 Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
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