Property Summary

NCBI Gene PubMed Count 114
Grant Count 124
R01 Count 59
Funding $11,496,332.09
PubMed Score 257.96
PubTator Score 202.79

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (28)

Disease log2 FC p
malignant mesothelioma -7.600 0.000
astrocytoma -5.500 0.000
ependymoma -5.400 0.001
oligodendroglioma -3.500 0.000
cutaneous lupus erythematosus 1.800 0.008
glioblastoma -4.400 0.000
osteosarcoma 1.991 0.022
medulloblastoma -5.300 0.000
periodontitis 1.400 0.000
atypical teratoid / rhabdoid tumor -4.200 0.000
medulloblastoma, large-cell -4.700 0.002
primitive neuroectodermal tumor -3.500 0.006
non-small cell lung cancer 1.150 0.000
intraductal papillary-mucinous adenoma (... -1.400 0.032
intraductal papillary-mucinous carcinoma... -1.900 0.015
lung cancer 1.300 0.005
Parkinson's disease -1.400 0.027
interstitial cystitis 1.300 0.049
pediatric high grade glioma -3.300 0.001
pilocytic astrocytoma -2.600 0.003
severe Alzheimer's disease -1.711 0.037
lung carcinoma 1.800 0.000
Pick disease -2.100 0.010
Breast cancer 2.200 0.000
ductal carcinoma in situ 1.400 0.021
ulcerative colitis 1.400 0.003
ovarian cancer -4.600 0.000
Down syndrome -1.300 0.012

Synonym

Accession P49798 A7XA56 A7XA58 A7XA59 A7YVV7 B1APZ3 RGP4
Symbols RGP4
SCZD9

Gene

PANTHER Protein Class (2)

MLP Assay (12)

AID Type Active / Inconclusive / Inactive Description
1872 confirmatory 27 / 0 / 158 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao.
2295 confirmatory 18 / 0 / 18 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao for SAR compounds
463111 screening 2824 / 0 / 302855 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4)
463165 screening 1365 / 0 / 304314 Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4)
485274 summary 0 / 0 / 0 Summary of probe development for potentiators of the regulator of G-protein signaling 4 (RGS4)
485289 summary 0 / 0 / 0 Summary of probe development for inhibitors of the regulator of G-protein signaling 4 (RGS4)
492999 screening 1078 / 0 / 584 Validation assay for identification of compounds that inhibit the regulator of G-protein signaling 4 (RGS4)
493000 screening 386 / 0 / 1539 Counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay
493001 screening 428 / 0 / 1497 Second counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay without carbachol activation
602282 screening 1022 / 0 / 125 Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4)
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Gene RIF (105)

PMID Text
26640232 All of these results confirmed the critical role of RGS4 in NSCLC progression.
26119705 After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
26088132 RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events.
25289860 RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.
24297163 ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected.
23911251 RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia.
23733193 Data indicate that Rab5, Rab7 and Rab11 are involved in RGS4 traffics through plasma membrane recycling or endosome.
23630294 dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants
23332465 genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA.
23093381 The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression.
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AA Sequence

MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHE      1 - 70
CGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRN     71 - 140
MLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA         141 - 205
//

Text Mined References (114)

PMID Year Title
26640232 2016 Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer.
26119705 2015 Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
26088132 2015 Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.
25289860 2015 RGS2 and RGS4 proteins: New modulators of the ?-opioid receptor signaling.
24297163 2014 Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
24009623 2013 Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
23911251 2013 RGS4 and COMT risk variants are associated with brain structural alterations.
23733193 2013 Rab family proteins regulate the endosomal trafficking and function of RGS4.
23630294 2013 Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.
23332465 2013 Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets.
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