Property Summary

NCBI Gene PubMed Count 26
PubMed Score 25.02
PubTator Score 83.92

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count
Stomach Neoplasms 282
Disease Target Count P-value
lung carcinoma 2844 5.46951003265483E-11
malignant mesothelioma 3163 1.20903462599487E-9
pilocytic astrocytoma 3086 3.76558234136503E-8
ovarian cancer 8492 8.79588938966341E-8
Breast cancer 3099 9.42263131123803E-8
glioblastoma 5572 7.54365435291871E-7
pituitary cancer 1972 5.54599069612247E-6
adult high grade glioma 2148 1.07918255714109E-5
cystic fibrosis 1670 1.48243632430815E-5
primary pancreatic ductal adenocarcinoma 1271 3.72519928815948E-5
posterior fossa group A ependymoma 1511 4.81667708612561E-5
atypical teratoid/rhabdoid tumor 1095 2.15250075341874E-4
lung cancer 4473 3.01671654501329E-4
sonic hedgehog group medulloblastoma 1482 8.16079135892339E-4
pancreatic cancer 2300 8.98034725509601E-4
Atopic dermatitis 944 0.00119436920067787
active Crohn's disease 918 0.00536066506815402
colon cancer 1475 0.00544267309735013
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0055540899138465
ductal carcinoma in situ 1745 0.00579285357793463
adrenocortical carcinoma 1427 0.00607652821773879
primary Sjogren syndrome 789 0.00858389861334211
gastric carcinoma 832 0.00937312135429908
psoriasis 6685 0.0191075484151655
esophageal adenocarcinoma 737 0.0195207517873976
cutaneous lupus erythematosus 1056 0.0306855265302289
osteosarcoma 7933 0.035609608760168
type II diabetes mellitus and post-ischemic heart failure 89 0.0366696563498382
pterygium 74 0.0388597278663604
interstitial cystitis 2299 0.0425246732648783
invasive ductal carcinoma 2950 0.0468246603931206



Accession P49788 Q8N1D7
Symbols LXNL


  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque EggNOG Inparanoid
Mouse OMA Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid

Gene RIF (17)

24014597 High TIG1 expression is associated with inflammatory breast cancer through activation of Axl kinase.
24006221 our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in hepatocellular carcinoma .
22942771 All-trans retinoic acid modulated secretion of RARRES1 in a dose dependent manner.
22669512 Analysis of a standard liver fibrosis model (CCl(4)) demonstrated an early induction of RARRES1 mRNA and protein expression.
22615834 Knocking-down CTCF expression hampered RARRES1 expression.
22573467 genotype-associated hypermethylation of the ETS-family target gene RARRES1 influences methylation at its neighbor gene LXN and could be useful as a prognostic biomarker.
22126303 TIG1 suppressed PGE2-stimulated Wnt and cAMP signaling pathways in colon cancer cells through GRK5.
21575264 GRK5 mediates cell growth suppression by TIG1A. Thus, TIG1 may participate in the downregulation of G-protein coupled signaling by upregulating GRK5 expression.
21303978 RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis.
21168224 The results of this study suggested that short RAI1 alleles might be releated to schizophreina disease.

AA Sequence

EEGSAVVPTELSNF                                                            281 - 294

Text Mined References (27)

PMID Year Title
24014597 2013 TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
24006221 2014 Aberrant TIG1 methylation associated with its decreased expression and clinicopathological significance in hepatocellular carcinoma.
22942771 2012 Secretome survey of human plexiform neurofibroma derived Schwann Cells reveals a secreted form of the RARRES1 protein.
22669512 2012 Identification of RARRES1 as a core regulator in liver fibrosis.
22615834 2012 Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding.
22573467 2012 The SNP rs6441224 influences transcriptional activity and prognostically relevant hypermethylation of RARRES1 in prostate cancer.
22126303 2011 Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth.
21575264 2011 G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells.
21303978 2011 Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the ?-tubulin tyrosination cycle.
21168224 2011 Retinoic acid induced 1 gene and clinical subtypes of schizophrenia: an association study.