Tbio EIF2B2 Translation initiation factor eIF-2B subunit beta

Protein Summary

Description

Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P49770
• O43201

Gene Name

• EIF2B2

Ensembl ID

• ENST00000266126
• ENSP00000266126
• ENSG00000119718

Symbol

• EIF2BB
• EIF2B
• EIF-2Bbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.99
molecular function	0.98
transcription factor perturbation	0.94
interacting protein	0.81

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.07   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 171   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.07   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0