Tchem CLK1 Dual specificity protein kinase CLK1

Protein Summary

Description

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• P49759
• B4DFW7
• Q0P694
• Q8N5V8

Gene Name

• CLK1

Ensembl ID

• ENST00000321356
• ENSP00000326830
• ENSG00000013441
• ENST00000432425
• ENSP00000400487
• ENST00000434813
• ENSP00000394734

Symbol

• CLK
• CLK
• STY
• CLK/STY

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule	0.98
molecular function	0.95
disease perturbation	0.87
phenotype	0.78
small molecule perturbation	0.78

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Clk Family / Dual Specificity Protein Kinase Clk1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.89   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.89   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3