Property Summary

NCBI Gene PubMed Count 57
PubMed Score 102.97
PubTator Score 94.39

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (7)

Disease Target Count P-value
psoriasis 6685 1.06096070647753E-74
non-small cell lung cancer 2798 1.53192637170868E-36
atypical teratoid / rhabdoid tumor 4369 1.20973765905321E-11
glioblastoma 5572 3.47707673093512E-10
ovarian cancer 8492 1.33393732582924E-9
lung adenocarcinoma 2714 6.82635666218623E-9
group 3 medulloblastoma 2254 1.93708219947914E-8
primitive neuroectodermal tumor 3031 6.18936286162471E-7
lung cancer 4473 8.20633987921143E-7
pediatric high grade glioma 2712 1.43626896110752E-6
medulloblastoma, large-cell 6234 1.58424264480186E-6
posterior fossa group A ependymoma 1511 1.6247727387572E-6
pancreatic cancer 2300 4.88356516241253E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 6.14668845435619E-6
breast carcinoma 1614 6.73829329241353E-6
Atopic dermatitis 944 5.71107505118644E-5
invasive ductal carcinoma 2950 6.06765699375623E-5
nasopharyngeal carcinoma 1056 7.80445041718799E-5
malignant mesothelioma 3163 8.61092653468479E-5
adrenocortical carcinoma 1427 1.41503653278709E-4
ductal carcinoma in situ 1745 3.68407811602171E-4
colon cancer 1475 0.00174879744359661
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00254427521449736
Endometriosis 535 0.00723559014278876
Breast cancer 3099 0.0215258560780546
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Primary ciliary dyskinesia 75 0.0 4.0
Disease Target Count Z-score Confidence
Cancer 2346 3.532 1.8
Disease Target Count
Stromme syndrome 1

Expression

Synonym

Accession P49454 Q13171 Q13246 Q5VVM7 CENP-F
Symbols CENF
hcp-1
CILD31
STROMS
PRO1779

Gene

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG

Gene RIF (33)

PMID Text
26259702 Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.
26188054 Mitosin and pHH3 immunostaining predict poorer survival in astrocytomas WHO grades II and III.
26101217 N-terminal microtubule-binding domain of CENP-F prefers curled oligomers of tubulin relative to microtubule walls by approximately fivefold, suggesting it may contribute to the firm bonds between kinetochores and flared plus ends of dynamic microtubules
25647485 the increased expression of CENPF plays an important role in the progression of PCa.
25564561 Our data identify CENPF as a new centriolar disease gene implicated in severe human ciliopathy and microcephaly related phenotypes
24823640 FOXM1 and CENPF function synergistically to promote tumor growth by coordinated regulation of target gene expression and activation of key signaling pathways associated with prostate cancer malignancy.
23791740 data suggest that CENPF is frequently overexpressed in HCC and plays a critical role in driving HCC tumorigenesis
23163484 CENP-F may serve as valuable molecular marker for predicting prognosis of ESCC patients. data indicate potential benefit of combining ZOL with cisplatin in ESCC; CENP-F expressionmay have therapeutic implications.
23097494 Data suggest that ASUN promotes perinuclear enrichment of dynein at G2/M that facilitates BICD2- and CENP-F-mediated anchoring of dynein to nuclear pore complexes.
22912832 Coincidently amplified CDK13, GMNN, and CENPF genes can play a role as common cancer-driver genes in human cancers.
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AA Sequence

MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQ      1 - 70
RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN     71 - 140
PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARH    141 - 210
QASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL    211 - 280
DQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQY    281 - 350
DQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKAR    351 - 420
LTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL    421 - 490
LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAV    491 - 560
ADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL    561 - 630
TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAY    631 - 700
MELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK    701 - 770
DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE    771 - 840
SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE    841 - 910
KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLK    911 - 980
EINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKN    981 - 1050
SKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNN   1051 - 1120
SKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNF   1121 - 1190
KPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG   1191 - 1260
LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECIT   1261 - 1330
ATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEV   1331 - 1400
QMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEE   1401 - 1470
GLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQTYVDSLKA   1471 - 1540
ENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEG   1541 - 1610
VVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQEL   1611 - 1680
EQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRS   1681 - 1750
LLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGE   1751 - 1820
QSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRD   1821 - 1890
RKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSE   1891 - 1960
GLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC   1961 - 2030
LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQV   2031 - 2100
AEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES   2101 - 2170
LQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKE   2171 - 2240
RERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKEN   2241 - 2310
LTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA   2311 - 2380
TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEH   2381 - 2450
AALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQE   2451 - 2520
KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKN   2521 - 2590
NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE   2591 - 2660
LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE   2661 - 2730
LQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLH   2731 - 2800
EAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK   2801 - 2870
MDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIK   2871 - 2940
ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIP   2941 - 3010
SVTEKRLSSGQNKASGKRQRSSGIWENGRGPTPATPESFSKKSKKAVMSGIHPAEDTEGTEFEPEGLPEV   3011 - 3080
VKKGFADIPTGKTSPYILRRTTMATRTSPRLAAQKLALSPLSLGKENLAESSKPTAGGSRSQKVKVAQRS   3081 - 3150
PVDSGTILREPTTKSVPVNNLPERSPTDSPREGLRVKRGRLVPSPKAGLESNGSENCKVQ             3151 - 3210
//

Text Mined References (71)

PMID Year Title
26820108 2016 Strømme Syndrome Is a Ciliary Disorder Caused by Mutations in CENPF.
26259702 2015 Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
26188054 2016 Mitosin and pHH3 predict poorer survival in astrocytomas WHO grades II and III.
26101217 2015 Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules.
25647485 2015 Enhanced expression of centromere protein F predicts clinical progression and prognosis in patients with prostate cancer.
25564561 2015 The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes.
24823640 2014 Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.
23791740 2013 Characterization of the oncogenic function of centromere protein F in hepatocellular carcinoma.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23163484 2013 Prognostic relevance and therapeutic implications of centromere protein F expression in patients with esophageal squamous cell carcinoma.
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