Property Summary

NCBI Gene PubMed Count 98
Grant Count 188
R01 Count 122
Funding $35,326,668.73
PubMed Score 532.85
PubTator Score 327.06

Knowledge Summary


No data available



Accession P49450 D6W544 Q53T74 Q9BVW2
Symbols CenH3



3AN2   3WTP   5CVD   3NQJ   3NQU   3R45  

Gene RIF (68)

26878239 The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).
26527398 CENP-C and CENP-I are key factors connecting kinetochore to CENP-A assembly.
25954010 CENP-C depletion leads to rapid removal of CENP-A from centromeres, indicating their collaboration in maintaining centromere identity.
25942623 CENP-B directly binds both CENP-A's amino-terminal tail and CENP-C, a key nucleator of kinetochore assembly
25843710 We used a synthetic system to dissect how CenH3(CENP-A) contributes to the accumulation of CENP-C and CENP-T, two key components that are necessary for the formation of functional kinetochores
25795299 the CRL4 complex containing RBBP7 (CRL4(RBBP7)) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.
25786215 The DNA ends of the CENP-A nucleosome are more flexible than those of the H3 nucleosome.
25713413 results indicate that the regions of CENP-A required for early events in centromere establishment differ from those that are required for maintaining centromere identity.
25408271 The CENP-A/histone H3.3 nucleosome forms an unexpectedly stable structure and allows the binding of the essential centromeric protein, CENP-C, which is ectopically mislocalized in the chromosomes of CENP-A overexpressing tumor cells.
25117489 The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A, implicating RNA-based chaperone targeting in histone variant assembly.

AA Sequence


Text Mined References (107)

PMID Year Title
27499292 2016 The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.
26878239 2016 CENP-C directs a structural transition of CENP-A nucleosomes mainly through sliding of DNA gyres.
26543159 2015 Molecular basis for histone N-terminal methylation by NRMT1.
26527398 2015 CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25954010 2015 Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.
25942623 2015 DNA Sequence-Specific Binding of CENP-B Enhances the Fidelity of Human Centromere Function.
25843710 2015 HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.
25795299 2015 CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.
25786215 2015 Two arginine residues suppress the flexibility of nucleosomal DNA in the canonical nucleosome core.