Tclin FNTA Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Protein Summary

Description

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P49354
• A6NJW0
• Q53XJ9
• Q9UDC1

Gene Name

• FNTA

Ensembl ID

• ENST00000302279
• ENSP00000303423
• ENSG00000168522

Symbol

• FPTA
• PTAR2
• PGGT1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.99
virus perturbation	0.99
transcription factor perturbation	0.88
cell type or tissue	0.81

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Protein Farnesyltransferase/geranylgeranyltransferase Type-1 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.61   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.61   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1