| Tbio | Ribose-5-phosphate isomerase |
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq, Mar 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Ribose 5-Phosphate Isomerase Deficiency | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 1.7e-06 |
| group 3 medulloblastoma | 4104 | 8.0e-05 |
| osteosarcoma | 7950 | 2.1e-02 |
| Waldenstrons macroglobulinemia | 765 | 3.4e-02 |
| Disease | Target Count |
|---|---|
| Ribose-5-P isomerase deficiency | 1 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.500 | 8.0e-05 |
| malignant mesothelioma | 1.800 | 1.7e-06 |
| osteosarcoma | -1.090 | 2.1e-02 |
| Waldenstrons macroglobulinemia | 1.225 | 3.4e-02 |
MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNSWDLPGSHVRLPGRAQSGTRGGAGNTSTSCGDSNSICP 1 - 70 APSTMSKAEEAKKLAGRAAVENHVRNNQVLGIGSGSTIVHAVQRIAERVKQENLNLVCIPTSFQARQLIL 71 - 140 QYGLTLSDLDRHPEIDLAIDGADEVDADLNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDQWH 141 - 210 KGIPIEVIPMAYVPVSRAVSQKFGGVVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWSEVNTAIKMIPG 211 - 280 VVDTGLFINMAERVYFGMQDGSVNMREKPFC 281 - 311 //
