Tchem NR2C2 Nuclear receptor subfamily 2 group C member 2

Protein Summary

Description

Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P49116
• A8K3H5
• B6ZGT8
• P55092

Gene Name

• NR2C2

Ensembl ID

• ENST00000323373
• ENSP00000320447
• ENSG00000177463
• ENST00000393102
• ENSP00000376814
• ENST00000406272
• ENSP00000384463
• ENST00000425241
• ENSP00000388387
• ENST00000617312
• ENSP00000483059

Symbol

• TAK1
• TR4
• TR4
• TAK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
kinase perturbation	0.84
histone modification site profile	0.81
biological process	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Receptor Subfamily 2 Group C Member 2

Protein / Receptor / Nuclear Receptor Subfamily 2 Group C Member 2

Protein / Nucleic Acid Binding / Nuclear Receptor Subfamily 2 Group C Member 2

Protein / ... / C4 Zinc Finger Nuclear Receptor / Nuclear Receptor Subfamily 2 Group C Member 2

DTO Classes

Protein / Nuclear Receptor / Testicular Receptors / Nuclear Receptor Subfamily 2 Group C Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.99   (req: < 5)

Gene RIFs: 96   (req: <= 3)

Antibodies: 448   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.99   (req: >= 5)

Gene RIFs: 96   (req: > 3)

Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2