Tchem HCAR3 Hydroxycarboxylic acid receptor 3

Protein Summary

Description

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

Uniprot Accession IDs

• P49019
• A8K4G5
• B2R830
• E9PI97
• Q8NGE4

Gene Name

• HCAR3

Ensembl ID

• ENST00000528880
• ENSP00000436714
• ENSG00000255398

Symbol

• GPR109B
• HCA3
• HM74B
• NIACR2
• HCA3
• HM74
• PUMAG
• Puma-g
• GPR109B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
gene perturbation	0.7
small molecule perturbation	0.64
tissue	0.63
PubMedID	0.62

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Hydroxycarboxylic Acid Receptor / Hydroxycarboxylic Acid Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.41   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0