| Tbio | CD151 antigen |
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Nephropathy with Pretibial Epidermolysis Bullosa and Deafness | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 6.7e-25 |
| ovarian cancer | 8520 | 1.1e-08 |
| ependymoma | 4679 | 5.4e-08 |
| pediatric high grade glioma | 1064 | 2.2e-05 |
| Astrocytoma, Pilocytic | 3081 | 6.9e-05 |
| sonic hedgehog group medulloblastoma | 467 | 6.3e-04 |
| glioblastoma | 5792 | 7.6e-04 |
| diabetes mellitus | 1728 | 3.6e-03 |
| subependymal giant cell astrocytoma | 2287 | 5.3e-03 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 3.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Epidermolysis bullosa | 21 | 0.0 | 4.0 |
| Disease | log2 FC | p |
|---|---|---|
| Astrocytoma, Pilocytic | 1.100 | 6.9e-05 |
| diabetes mellitus | -1.600 | 3.6e-03 |
| ependymoma | 1.200 | 5.4e-08 |
| glioblastoma | 1.100 | 7.6e-04 |
| lung carcinoma | -1.400 | 6.7e-25 |
| mucosa-associated lymphoid tissue lympho... | 1.184 | 3.2e-02 |
| ovarian cancer | -1.600 | 1.1e-08 |
| pediatric high grade glioma | 1.600 | 2.2e-05 |
| sonic hedgehog group medulloblastoma | 1.100 | 6.3e-04 |
| subependymal giant cell astrocytoma | 1.620 | 5.3e-03 |
