| Tbio | CD151 antigen |
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 107 |
| Grant Count | 92 |
| R01 Count | 74 |
| Funding | $10,733,322.17 |
| PubMed Score | 249.33 |
| PubTator Score | 204.73 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.500 | 0.000 |
| ependymoma | 1.200 | 0.000 |
| diabetes mellitus | -1.600 | 0.004 |
| pediatric high grade glioma | 1.600 | 0.000 |
| pilocytic astrocytoma | 1.100 | 0.000 |
| sonic hedgehog group medulloblastoma | 1.100 | 0.001 |
| subependymal giant cell astrocytoma | 1.620 | 0.005 |
| lung carcinoma | -1.400 | 0.000 |
| mucosa-associated lymphoid tissue lympho... | 1.184 | 0.032 |
| ovarian cancer | -1.600 | 0.000 |
| PMID | Text |
|---|---|
| 26707073 | CD151 knockdown inhibits the expression of MMP9 through the GSK-3b/bcatenin pathway and also inhibits Osteosarcoma (OS)migration and invasion in vitro and metastasis in vivo in highly metastatic OS. |
| 26464707 | In high grade DCIS, when stratified according to the HER2 status, in the HER2-negative subgroup, CD151 assessed in combination with alpha3beta1 was significantly correlated with prognosis. |
| 26418968 | the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion. |
| 26377974 | Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility. |
| 26245294 | selective interaction with PY12 oligomers is crucial for platelet aggregation and thrombus stabilization |
| 26136426 | Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation. |
| 25356755 | our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling |
| 25351816 | Knockdown CD151 expression by targeted siRNA could inhibit the related downstream intercellular signaling pathways including FAK, PI3KAKT, MEKERK1/2MAPK as well as the expression of MMP9 and VEGF. |
| 25275127 | HIV-1 Nef downregulates the cell surface expression of CD151 (TSPAN24) |
| 25119599 | Increased expression of CD151 is associated with gastric cancer. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 26707073 | 2016 | CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3?/?-catenin/MMP9 pathway. |
| 26464707 | 2015 | Expression of CD151/Tspan24 and integrin alpha 3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ. |
| 26418968 | 2015 | CD151 promotes ?3?1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion. |
| 26377974 | 2015 | CD151-?3?1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. |
| 26245294 | 2015 | A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets. |
| 26136426 | 2015 | Tetraspanin CD151 Is a Negative Regulator of Fc?RI-Mediated Mast Cell Activation. |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25356755 | 2014 | CD151-?3?1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. |
| 25351816 | 2015 | Effects of tetraspanin CD151 inhibition on A549 human lung adenocarcinoma cells. |
| 25241909 | 2014 | Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. |
| More... |
