Tbio | CD151 antigen |
(Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count |
---|---|
Bronchitis, Chronic | 9 |
Chronic Obstructive Airway Disease | 47 |
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 6.6765630999969E-25 |
ovarian cancer | 8492 | 1.11621010971842E-8 |
ependymoma | 2514 | 5.35485896156189E-8 |
pediatric high grade glioma | 2712 | 2.23499718598058E-5 |
pilocytic astrocytoma | 3086 | 8.34966872108145E-5 |
glioblastoma | 5572 | 4.1128467102613E-4 |
sonic hedgehog group medulloblastoma | 1482 | 6.32611984964687E-4 |
diabetes mellitus | 1663 | 0.00363301696551453 |
subependymal giant cell astrocytoma | 2287 | 0.00531233981091074 |
mucosa-associated lymphoid tissue lymphoma | 480 | 0.0323835719146515 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Epidermolysis bullosa | 21 | 0.0 | 4.0 |
Disease | Target Count |
---|---|
Nephropathy with pretibial epidermolysis bullosa and deafness | 1 |
Disease | log2 FC | p |
---|---|---|
glioblastoma | 1.500 | 0.000 |
ependymoma | 1.200 | 0.000 |
diabetes mellitus | -1.600 | 0.004 |
pediatric high grade glioma | 1.600 | 0.000 |
pilocytic astrocytoma | 1.100 | 0.000 |
sonic hedgehog group medulloblastoma | 1.100 | 0.001 |
subependymal giant cell astrocytoma | 1.620 | 0.005 |
lung carcinoma | -1.400 | 0.000 |
mucosa-associated lymphoid tissue lympho... | 1.184 | 0.032 |
ovarian cancer | -1.600 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
26707073 | CD151 knockdown inhibits the expression of MMP9 through the GSK-3b/bcatenin pathway and also inhibits Osteosarcoma (OS)migration and invasion in vitro and metastasis in vivo in highly metastatic OS. |
26464707 | In high grade DCIS, when stratified according to the HER2 status, in the HER2-negative subgroup, CD151 assessed in combination with alpha3beta1 was significantly correlated with prognosis. |
26418968 | the role of the CD151-alpha3beta1 complex in carcinoma progression is context dependent, and may depend on the mode of tumor cell invasion. |
26377974 | Data show that CD151 protein (CD151)-alpha3beta1 integrin complexes cooperated with epidermal growth factor receptor (EGFR) to drive tumor cell motility. |
26245294 | selective interaction with PY12 oligomers is crucial for platelet aggregation and thrombus stabilization |
26136426 | Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation. |
25356755 | our study demonstrates that CD151-alpha3beta1 integrin complexes regulate ovarian tumor growth by repressing Slug-mediated epithelial to mesenchymal transition and Wnt signaling |
25351816 | Knockdown CD151 expression by targeted siRNA could inhibit the related downstream intercellular signaling pathways including FAK, PI3KAKT, MEKERK1/2MAPK as well as the expression of MMP9 and VEGF. |
25275127 | HIV-1 Nef downregulates the cell surface expression of CD151 (TSPAN24) |
25119599 | Increased expression of CD151 is associated with gastric cancer. |
More... |
PMID | Year | Title |
---|---|---|
26707073 | 2016 | CD151 knockdown inhibits osteosarcoma metastasis through the GSK-3?/?-catenin/MMP9 pathway. |
26464707 | 2015 | Expression of CD151/Tspan24 and integrin alpha 3 complex in aid of prognostication of HER2-negative high-grade ductal carcinoma in situ. |
26418968 | 2015 | CD151 promotes ?3?1 integrin-dependent organization of carcinoma cell junctions and restrains collective cell invasion. |
26377974 | 2015 | CD151-?3?1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion. |
26245294 | 2015 | A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets. |
26136426 | 2015 | Tetraspanin CD151 Is a Negative Regulator of Fc?RI-Mediated Mast Cell Activation. |
25416956 | 2014 | A proteome-scale map of the human interactome network. |
25356755 | 2014 | CD151-?3?1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling. |
25351816 | 2015 | Effects of tetraspanin CD151 inhibition on A549 human lung adenocarcinoma cells. |
25241909 | 2014 | Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. |
More... |