Tbio RFX3 Transcription factor RFX3

Protein Summary

Description

Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5) (By similarity). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• P48380
• A8K0H5
• D3DRH8
• D3DRH9
• Q5JTL7
• Q5JTL8
• Q6NW13
• Q8WTU4
• Q95HL5
• Q95HL6

Gene Name

• RFX3

Ensembl ID

• ENST00000302303
• ENSP00000303847
• ENSG00000080298
• ENST00000358730
• ENSP00000351574
• ENST00000382004
• ENSP00000371434
• ENST00000617270
• ENSP00000482598

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.92
transcription factor binding site profile	0.91
histone modification site profile	0.88
transcription factor	0.85
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Rfx3

Protein / ... / Winged Helix/forkhead Transcription Factor / Transcription Factor Rfx3

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Transcription Factor Rfx3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.88   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0