| Tbio | Transmembrane 4 L6 family member 4 |
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Liver diseases | 87 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 1.4e-08 |
| lung carcinoma | 2843 | 9.0e-06 |
| lung adenocarcinoma | 2716 | 4.6e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 3.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| intraductal papillary-mucinous adenoma (... | -2.500 | 3.7e-02 |
| lung adenocarcinoma | 1.400 | 4.6e-03 |
| lung carcinoma | 1.900 | 9.0e-06 |
| malignant mesothelioma | -3.500 | 1.4e-08 |
