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Tbio Transmembrane 4 L6 family member 4

Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 8.49
PubTator Score 9.85

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Liver diseases 87 0.0 0.0

Expression

  Differential Expression (4)

Disease log2 FC p
intraductal papillary-mucinous adenoma (... -2.500 3.7e-02
lung adenocarcinoma 1.400 4.6e-03
lung carcinoma 1.900 9.0e-06
malignant mesothelioma -3.500 1.4e-08

Synonym

Accession P48230 B2RDA4
Symbols ILTMP
il-TMP

Gene

TM4SF4

  Ortholog (14)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (6)

 GO Component (1)

 GO Process (1)

 Compartment GO Term (10)

 IMPC Phenotype (1)

 MGI Phenotype (1)

 GWAS Trait (2)

 HCA RNA Cell Line (40)

See all...

Gene RIF (6)

AA Sequence 

MCTGGCARCLGGTLIPLAFFGFLANILLFFPGGKVIDDNDHLSQEIWFFGGILGSGVLMIFPALVFLGLK      1 - 70
NNDCCGCCGNEGCGKRFAMFTSTIFAVVGFLGAGYSFIISAISINKGPKCLMANSTWGYPFHDGDYLNDE     71 - 140
ALWNKCREPLNVVPWNLTLFSILLVVGGIQMVLCAIQVVNGLLGTLCGDCQCCGCCGGDGPV            141 - 202
//

Text Mined References (16)

PMID Year Title