| Tbio | Transmembrane 4 L6 family member 4 |
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]
Comments
| Disease | Target Count |
|---|---|
| Liver diseases | 66 |
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3163 | 1.42415090893821E-8 |
| lung carcinoma | 2844 | 9.04783863004912E-6 |
| lung adenocarcinoma | 2714 | 0.00455904777471919 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 0.0365483288740649 |
| Disease | log2 FC | p |
|---|---|---|
| malignant mesothelioma | -3.500 | 0.000 |
| intraductal papillary-mucinous adenoma (... | -2.500 | 0.037 |
| lung adenocarcinoma | 1.400 | 0.005 |
| lung carcinoma | 1.900 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 25344917 | TM4SF4 expression was correlated with the increased expression of IGF1, consequently resulting in IGF1R activation in lung adenocarcinoma. |
| 24282057 | TM4SF4 interacts with hTHTR-2 and influences the physiological function of the thiamine transporter in human intestinal epithelial cells. |
| 23296076 | TM4SF4 is a membrane protein that may have a role in attenuating liver cancer cell growth |
| 22011044 | Results suggest that S100B, TM4SF3, and OLFM4 overexpression may affect metastatic behavior of tumor cells in Taiwanese colorectal cancer patients. |
| 18765015 | expression of transmembrane 4 superfamily member 4 (TM4SF4) and matrix metalloproteinase 26 (MMP26) was found to be significantly decreased during the implantation window in patients with polycystic ovary syndrome. |
| PMID | Year | Title |
|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. |
| 25344917 | 2014 | TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. |
| 24282057 | 2014 | Association of TM4SF4 with the human thiamine transporter-2 in intestinal epithelial cells. |
| 23296076 | 2013 | Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo. |
| 22011044 | 2012 | Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients. |
| 19159218 | 2009 | Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. |
| 18765015 | 2008 | Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome. |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| 15342556 | 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
| More... |
