Property Summary

NCBI Gene PubMed Count 17
PubMed Score 163.73
PubTator Score 19.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (4)

Disease Target Count
Melanoma 261
Disease Target Count P-value
atypical teratoid/rhabdoid tumor 1095 1.19552329229459E-7
group 4 medulloblastoma 1875 3.62348612379224E-6
medulloblastoma, large-cell 6234 1.20945633811232E-4
glioblastoma 5572 0.00770928746236701
non primary Sjogren syndrome sicca 840 0.0232974637107004
pediatric high grade glioma 2712 0.0441233127202907
Disease Target Count Z-score Confidence
Rheumatoid Arthritis 1171 0.0 2.0

Expression

  Differential Expression (6)

Synonym

Accession P48066 B2R6U6 Q8IYC9 GAT-3
Symbols GAT3
GAT4
GAT-3

Gene

PANTHER Protein Class (2)

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid

Gene RIF (11)

PMID Text
26212582 GABA-transporter 3 was reduced by about 62% in severe hippocampal sclerosis samples
25256099 3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 results in intellectual disability, epilepsy and stereotypic behavior.
23795861 results suggest that GABA receptor signaling pathway was associated with the increased susceptibility to TD in Korean schizophrenic patients
23225341 Binding assays employing membrane preparations obtained from a stably GAT3 expressing HEK293 cell line and DDPM-1007 as nonlabeled GAT3 marker were performed. In these experiments specific binding of DDPM-1007 at GAT3 could be unambiguously detected.
21776001 The results suggest that GAT3 c.1572T may be one of the contributing factors with a modest effect on antiepileptic drug (AEDs) pharmacoresistance in the epileptic brain.
20424473 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19874574 Observational study of gene-disease association. (HuGE Navigator)
19450549 homology models of hGAT-2 and hGAT-3 were built and searched for (i) substrate conformation, (ii) prediction of substrate (inhibitor) interaction, and (iii) distinguishable allosteric Zn2+ inhibition by combining docking and MD calculations.
19086053 Observational study of gene-disease association. (HuGE Navigator)
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AA Sequence

MTAEKALPLGNGKAAEEARESEAPGGGCSSGGAAPARHPRVKRDKAVHERGHWNNKVEFVLSVAGEIIGL      1 - 70
GNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIE     71 - 140
AHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTENCVEFQKLNVSNYSHVSLQNATSPVMEFWEHR    141 - 210
VLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASE    211 - 280
GIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGF    281 - 350
AIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVT    351 - 420
AVVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECICIGWV    421 - 490
YGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGYGIGWLMALS    491 - 560
SMLCIPLWICITVWKTEGTLPEKLQKLTTPSTDLKMRGKLGVSPRMVTVNDCDAKLKSDGTIAAITEKET    561 - 630
HF                                                                        631 - 632
//

Text Mined References (19)

PMID Year Title
26212582 2015 Hippocampal GABA transporter distribution in patients with temporal lobe epilepsy and hippocampal sclerosis.
25256099 2014 3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 results in intellectual disability, epilepsy and stereotypic behavior.
25221879 2014 Genome-wide interrogation of longitudinal FEV1 in children with asthma.
23795861 2014 Gaba transporter SLC6A11 gene polymorphism associated with tardive dyskinesia.
23225341 2013 Development and validation of an LC-ESI-MS/MS quantification method for a potential ?-aminobutyric acid transporter 3 (GAT3) marker and its application in preliminary MS binding assays.
22491018 2013 Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.
21776001 2011 Association of a synonymous GAT3 polymorphism with antiepileptic drug pharmacoresistance.
20424473 2010 L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19874574 2009 Genetical genomic determinants of alcohol consumption in rats and humans.
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