Property Summary

NCBI Gene PubMed Count 31
PubMed Score 31.05
PubTator Score 34.58

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 4.57050045514684E-27
Breast cancer 3099 3.36896811098285E-12
malignant mesothelioma 3163 7.79898857793161E-10
ovarian cancer 8492 7.82391205650086E-9
pilocytic astrocytoma 3086 1.56254492059293E-8
atypical teratoid / rhabdoid tumor 4369 8.66899077415044E-6
ulcerative colitis 2087 1.80901639247502E-5
interstitial cystitis 2299 2.34121955825932E-5
psoriasis 6685 8.15810275606451E-5
lung cancer 4473 1.71209797076642E-4
medulloblastoma, large-cell 6234 5.54931359856676E-4
pediatric high grade glioma 2712 7.22506774139286E-4
primary Sjogren syndrome 789 0.00113989137496862
medulloblastoma 1524 0.00172676007820602
cystic fibrosis 1670 0.0023053470686651
posterior fossa group A ependymoma 1511 0.00238397827752993
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00292806025346338
glioblastoma 5572 0.0031567913901162
osteosarcoma 7933 0.00486982697473113
cutaneous lupus erythematosus 1056 0.0053065685540498
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00624039108701903
head and neck cancer 270 0.00904258444276116
subependymal giant cell astrocytoma 2287 0.00960250481271652
gastric carcinoma 832 0.0119803264766776
diabetes mellitus 1663 0.0219286533073644
tuberculosis and treatment for 6 months 686 0.0275746894518425
pancreatic cancer 2300 0.0285853484634913
aldosterone-producing adenoma 664 0.0357278510859593
chronic kidney disease 90 0.0366098571483262
primary pancreatic ductal adenocarcinoma 1271 0.038016834834879
oligodendroglioma 2849 0.0462009664988403
Disease Target Count Z-score Confidence
Cancer 2346 3.048 1.5



Accession P48060 A7YET6 F8VUC2 Q15409 Q969K2 GliPR 1
Symbols GLIPR


PANTHER Protein Class (1)


3Q2R   3Q2U  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG

Gene RIF (21)

26988096 This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth.
26305187 RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein.
26267319 Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells.
24008279 Based on the observed overexpression in AML samples, GliPR1 should be further explored as a potential target for AML
23714687 miR-137 inhibits Glioblastom stem cell self-renewal and promotes their differentiation by targeting RTVP-1 which down-regulates CXCR4.
23433894 Data indicate that combining adenoviral vector-mediated GLIPR1 gene therap (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors.
23333597 GLIPR1 interacts with Hsc70, and GLIPR1 overexpression or Hsc70 knockdown leads to transcriptional suppression of AURKA and TPX2.
22025562 Data show that the expression of GLIPR1 and c-Myc were inversely correlated in prostate cancer.
21931216 GLIPR1 core structure has a conserved central cavity via which CAP proteins are likely to bind to shared ligands.
21922325 demonstrate that GLIPR1 is a methylation-silenced gene in the acute myeloid leukemia patients

AA Sequence


Text Mined References (31)

PMID Year Title
26988096 2016 GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
26305187 2015 RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.
26267319 2015 RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop.
24008279 2013 Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.
23714687 2013 MicroRNA-137 is downregulated in glioblastoma and inhibits the stemness of glioma stem cells by targeting RTVP-1.
23433894 2014 Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.
23333597 2013 Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.
22025562 2011 GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.
21931216 2011 Structural studies of human glioma pathogenesis-related protein 1.
21922325 2011 Identification of GLIPR1 tumor suppressor as methylation-silenced gene in acute myeloid leukemia by microarray analysis.