Tclin GRIA4 Glutamate receptor 4

Protein Summary

Description

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48058
• Q86XE8
• GluR-4

Gene Name

• GRIA4

Ensembl ID

• ENST00000282499
• ENSP00000282499
• ENSG00000152578
• ENST00000393125
• ENSP00000376833
• ENST00000428631
• ENSP00000415551
• ENST00000530497
• ENSP00000435775

Symbol

• GLUR4
• GLUR4
• GLURD
• GluA4
• GLUR4C
• NEDSGA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.92
molecular function	0.81
microRNA	0.74
protein domain	0.73
ligand (chemical)	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Gria4 Subfamily / Glutamate Receptor 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.66   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 415   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.66   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 92

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6