Tchem KCNJ6 G protein-activated inward rectifier potassium channel 2

Protein Summary

Description

This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]

Uniprot Accession IDs

• P48051
• Q3MJ74
• Q53WW6
• GIRK-2

Gene Name

• KCNJ6

Ensembl ID

• ENST00000609713
• ENSP00000477437
• ENSG00000157542
• ENST00000645093
• ENSP00000493772

Symbol

• GIRK2
• KATP2
• KCNJ7
• BIR1
• GIRK2
• KATP2
• KCNJ7
• KPLBS
• GIRK-2
• KATP-2
• KIR3.2
• hiGIRK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
trait	0.75
phenotype	0.7
transcription factor binding site profile	0.66
ligand (chemical)	0.63

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj6 Subfamily / G Protein-activated Inward Rectifier Potassium Channel 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.81   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 356.81   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11