Tbio NPTX2 Neuronal pentraxin-2

Protein Summary

Description

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P47972
• A4D267
• Q86XV7
• Q96G70
• NP2

Gene Name

• NPTX2

Ensembl ID

• ENST00000265634
• ENSP00000265634
• ENSG00000106236

Symbol

• NP2
• NARP
• NP-II

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.9
kinase perturbation	0.81
disease perturbation	0.62
transcription factor	0.62
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.58   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.58   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0