HTR5A
5-hydroxytryptamine receptor 5A
Protein Summary
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
- ENST00000287907
- ENSP00000287907
- ENSG00000157219
- ENST00000650536
- ENSP00000497571
- 5-HT5A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (chemical) | 0.8 | ||
gene perturbation | 0.59 | ||
protein domain | 0.58 | ||
cell type or tissue | 0.52 | ||
cellular component | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.02 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 329 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 75.02 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 329 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 108
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 9