Property Summary

NCBI Gene PubMed Count 81
PubMed Score 30.15
PubTator Score 39.12

Knowledge Summary

Patent (3,978)


  Disease Sources (5)

Disease Target Count
Schizophrenia 503
Disease Target Count P-value
ependymoma 2514 2.27613054685859E-18
astrocytoma 1493 3.83738029196919E-16
oligodendroglioma 2849 2.37694013352029E-14
atypical teratoid / rhabdoid tumor 4369 1.20036155701484E-12
ovarian cancer 8492 4.28666073275173E-8
pilocytic astrocytoma 3086 8.73018446628247E-8
pediatric high grade glioma 2712 9.28097805042054E-8
osteosarcoma 7933 6.91635825423637E-7
glioblastoma 5572 1.02738915062846E-6
medulloblastoma, large-cell 6234 2.06025865247102E-6
medulloblastoma 1524 2.9351963823979E-6
adrenocortical carcinoma 1427 4.35100874906535E-5
primitive neuroectodermal tumor 3031 7.94547342556549E-4
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00289084398506304
chronic lymphosyte leukemia 232 0.0210334221886597
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0


  Differential Expression (15)

Disease log2 FC p
astrocytoma -3.900 0.000
ependymoma -6.500 0.000
oligodendroglioma -4.200 0.000
glioblastoma -6.900 0.000
osteosarcoma 1.259 0.000
chronic lymphosyte leukemia 1.300 0.021
medulloblastoma -5.000 0.000
atypical teratoid / rhabdoid tumor -7.200 0.000
medulloblastoma, large-cell -4.700 0.000
primitive neuroectodermal tumor -4.800 0.001
adrenocortical carcinoma -1.733 0.000
intraductal papillary-mucinous neoplasm ... 1.700 0.003
pediatric high grade glioma -6.100 0.000
pilocytic astrocytoma -4.900 0.000
ovarian cancer -2.300 0.000



  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Fruitfly OMA Inparanoid

  TechDev Info (1)

Susumu Tomita Biochemical interactoin

Gene RIF (65)

26561861 Data show evidence for the schizophrenia candidate gene gamma-aminobutyric acid A receptor beta 2 (GABRB2) to play a role in heroin dependence.
26016529 Deletion of the N-terminal extension and putative alpha-helix in heteromeric alpha1beta2gamma2 GABAA receptors in the beta2 subunit affected GABA sensitivity and desensitization.
25241062 Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway
25124326 Our findings underscore the need for further investigation into the mechanisms by which mutations in GABRB2 contribute to neurological and developmental dysfunction.
23917429 This study demonstrates altered patterns of N-glycosylation of GABRB2 in the temporal lobe in schizophrenia.
23638040 These findings revealed that GABRB2 is associated with psychosis, the core symptom and an endophenotype of schizophrenia.
23617850 high expression of GABBR2 with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer
23308109 Presented is a full-length alpha(1)beta(2)gamma(2) GABA(A) receptor model optimized for agonists and benzodiazepine allosteric modulators.
23266428 Report additive inhibition of human alpha1beta2gamma2 GABAA receptors by mixtures of commonly used drugs of abuse.
23121119 Mutation of GABA receptor beta2 subunit tyrosine residues in the binding pocket shifts the GABA concentration-response curve; GABA binding rates are reduced by mutation to binding pocket tyrosines.

AA Sequence

SRIFFPVVFSFFNIVYWLYYVN                                                    491 - 512

Text Mined References (82)

PMID Year Title
26561861 2015 GABRB2 Haplotype Association with Heroin Dependence in Chinese Population.
26016529 2015 Assembly, trafficking and function of ?1?2?2 GABAA receptors are regulated by N-terminal regions, in a subunit-specific manner.
25241062 2014 GABAB1 and GABAB2 receptor subunits co-expressed in cultured human RPE cells regulate intracellular Ca2+ via Gi/o-protein and phospholipase C pathways.
25124326 2014 A novel variant in GABRB2 associated with intellectual disability and epilepsy.
23917429 2014 N-Glycosylation of GABAA receptor subunits is altered in Schizophrenia.
23638040 2013 Social cognitive role of schizophrenia candidate gene GABRB2.
23617850 2013 Expression of gamma-aminobutyric acid receptors on neoplastic growth and prediction of prognosis in non-small cell lung cancer.
23308109 2013 A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites.
23266428 2013 Additive inhibition of human ?1?2?2 GABAA receptors by mixtures of commonly used drugs of abuse.
23121119 2013 Multiple tyrosine residues at the GABA binding pocket influence surface expression and mediate kinetics of the GABAA receptor.