GABRA2
Gamma-aminobutyric acid receptor subunit alpha-2
Protein Summary
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
- ENST00000356504
- ENSP00000348897
- ENSG00000151834
- ENST00000381620
- ENSP00000371033
- ENST00000510861
- ENSP00000421828
- ENST00000514090
- ENSP00000421300
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 0.95 | ||
protein domain | 0.92 | ||
molecular function | 0.9 | ||
disease perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.91 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 177.91 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 118
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 28