Tbio RAP1GAP Rap1 GTPase-activating protein 1

Protein Summary

Description

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state. This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• P47736
• J3QSS6
• O75062
• Q5T3S9
• Q5T3T4
• Q7Z5S8
• Q9UQ51
• Rap1GAP

Gene Name

• RAP1GAP

Ensembl ID

• ENST00000374765
• ENSP00000363897
• ENSG00000076864
• ENST00000495204
• ENSP00000434033
• ENST00000542643
• ENSP00000441661

Symbol

• KIAA0474
• RAP1GA1
• RAPGAP
• RAP1GA1
• RAP1GAP1
• RAP1GAPII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
molecular function	0.79
transcription factor	0.77
small molecule perturbation	0.68
hub protein	0.67

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Rap1 Gtpase-activating Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Rap1 Gtpase-activating Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.85   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.85   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0