Tchem PLA2G4A Cytosolic phospholipase A2

Protein Summary

Description

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P47712
• B1AKG4
• Q29R80
• cPLA2

Gene Name

• PLA2G4A

Ensembl ID

• ENST00000367466
• ENSP00000356436
• ENSG00000116711

Symbol

• CPLA2
• PLA2G4
• GURDP
• cPLA2
• PLA2G4
• cPLA2-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.99
interacting protein	0.99
metabolite	0.95
biological term	0.94
gene perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / Cytosolic Phospholipase A2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753   (req: < 5)

Gene RIFs: 160   (req: <= 3)

Antibodies: 362   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 753   (req: >= 5)

Gene RIFs: 160   (req: > 3)

Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 169

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0