Property Summary

NCBI Gene PubMed Count 61
Grant Count 49
R01 Count 35
Funding $5,180,984.66
PubMed Score 105.70
PubTator Score 88.33

Knowledge Summary


No data available


Gene RIF (41)

25684507 High expression of IER3 is associated with hepatocarcinoma.
25666857 findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
25066273 interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1.
25036043 In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
24311782 the interference of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
24162774 HIV-1 gp120 upregulates the expression of immediate early response 3 (IER3) in human B cells
23725081 IEX-1 expression levels correlate with the severity of preeclampsia
23403649 Studied the binding effect of hcmv-miR-UL148D to the 3' untranslated region (3'UTR) of IEX-1.Results showed that only one binding site in the 3'UTR of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir-UL148D.
22085302 Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.
21518511 Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.

AA Sequence

YALDLSTFLQQHPAAF                                                          141 - 156

Text Mined References (64)

PMID Year Title
25684507 2015 Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters.
25666857 2015 IER3 is a crucial mediator of TAp73?-induced apoptosis in cervical cancer and confers etoposide sensitivity.
25066273 2014 Transcription factor Elk-1 participates in the interleukin-1?-dependent regulation of expression of immediate early response gene 3 (IER3).
25036043 2014 The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.
24311782 2014 Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
23725081 2013 The expression of immediate early response gene X-1 in preeclampsia placenta and its pro-apoptotic role in preeclampsia.
23455636 2013 Seven new loci associated with age-related macular degeneration.
23403649 2013 Identification of immediate early gene X-1 as a cellular target gene of hcmv-mir-UL148D.
22565310 2012 Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
22085302 2011 Clinical significance of IEX-1 expression in ovarian carcinoma.