Property Summary

NCBI Gene PubMed Count 61
PubMed Score 105.70
PubTator Score 88.33

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 5.21514248526822E-10
lung adenocarcinoma 2714 7.39630214939616E-9
malignant mesothelioma 3163 3.62848452397714E-8
ovarian cancer 8492 1.1549326620789E-6
ulcerative colitis 2087 6.4730757649868E-6
tuberculosis 1563 4.37891077244127E-5
adrenocortical carcinoma 1427 6.96229203828248E-5
lung cancer 4473 1.07430067721371E-4
pituitary cancer 1972 1.12152397134663E-4
pilocytic astrocytoma 3086 3.18712622493279E-4
ductal carcinoma in situ 1745 6.88033225291614E-4
interstitial cystitis 2299 0.0017672356913547
posterior fossa group A ependymoma 1511 0.00177081477979323
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00315168949588292
atypical teratoid/rhabdoid tumor 1095 0.00481158595397443
glioblastoma 5572 0.00618913169828855
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00638627176494525
mucosa-associated lymphoid tissue lymphoma 480 0.0064478865626482
chronic rhinosinusitis 512 0.0114928067876432
invasive ductal carcinoma 2950 0.0155113711551069
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0155802116818214
X-linked cerebral adrenoleukodystrophy 115 0.0241012909019113
acute myeloid leukemia 785 0.0246855785622424
group 3 medulloblastoma 2254 0.0293745471854472
Disease Target Count Z-score Confidence
Congenital nonspherocytic hemolytic anemia 5 3.289 1.6



Accession P46695 Q5SU30 Q92691 Q93044
Symbols DIF2


  Ortholog (8)

Species Source
Chimp OMA Inparanoid
Macaque OMA Inparanoid
Mouse OMA Inparanoid
Rat OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Anole lizard OMA Inparanoid

Gene RIF (41)

25684507 High expression of IER3 is associated with hepatocarcinoma.
25666857 findings suggest that IER3 is a putative tumor suppressor in the cervix, and the c-Ab1/p73beta/IER3 axis is a novel and crucial signaling pathway that confers etoposide chemosensitivity.
25066273 interleukin-1beta (IL-1beta)-induced IER3 expression is mediated by the ERK1/2 target, transcription factor Elk-1.
25036043 In human samples removed from failed AVF, there was a significant increase in IEX-1 expression localized to the adventitia.
24311782 the interference of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
24162774 HIV-1 gp120 upregulates the expression of immediate early response 3 (IER3) in human B cells
23725081 IEX-1 expression levels correlate with the severity of preeclampsia
23403649 Studied the binding effect of hcmv-miR-UL148D to the 3' untranslated region (3'UTR) of IEX-1.Results showed that only one binding site in the 3'UTR of IEX-1 was completely complementary to an 11nt sequence in the 5' terminus of hcmv-mir-UL148D.
22085302 Altered IEX-1 expression can potentially be a new predictor of the malignant transformation and a prognostic indicator for cancer therapy.
21518511 Changes of methylation status of gene IEX-1 promoter CpG island correlates with hematologic malignancies.

AA Sequence

YALDLSTFLQQHPAAF                                                          141 - 156

Text Mined References (64)

PMID Year Title
25684507 2015 Expression of IER3 in primary hepatocarcinoma: correlation with clinicopathological parameters.
25666857 2015 IER3 is a crucial mediator of TAp73?-induced apoptosis in cervical cancer and confers etoposide sensitivity.
25066273 2014 Transcription factor Elk-1 participates in the interleukin-1?-dependent regulation of expression of immediate early response gene 3 (IER3).
25036043 2014 The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula.
24311782 2014 Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress.
23725081 2013 The expression of immediate early response gene X-1 in preeclampsia placenta and its pro-apoptotic role in preeclampsia.
23455636 2013 Seven new loci associated with age-related macular degeneration.
23403649 2013 Identification of immediate early gene X-1 as a cellular target gene of hcmv-mir-UL148D.
22565310 2012 Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
22085302 2011 Clinical significance of IEX-1 expression in ovarian carcinoma.