Property Summary

NCBI Gene PubMed Count 26
Grant Count 24
R01 Count 12
Funding $2,293,056.32
PubMed Score 46.21
PubTator Score 27.89

Knowledge Summary

Patent (8,887)

Expression

  Differential Expression (3)

Disease log2 FC p
medulloblastoma, large-cell 1.700 0.000
adult high grade glioma 1.100 0.000
ovarian cancer 1.100 0.000

Gene RIF (14)

PMID Text
26966045 Demonstrate equivalence between human and mouse XCR1(+) dendritic cells and human and mouse Langerhans cells.
26166822 results indicate that XCR1 is a new potential therapeutic target for the treatment of lung cancer bone metastasis
25520399 Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.
22964431 XCR1 is expressed early during the course of tumorigenic transformation and contributes towards increased cell migration and proliferation, which can facilitate the prometastatic behavior of epithelial ovarian cancer cells.
21948982 CD8alpha-positive dendritic cells (DCs) and CD103-positive DCs belong to a common DC subset which is unequivocally identified by XCR1 transgene expression despite their different anatomical locations.
21514207 Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility
21411777 XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow.
20541533 The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets.
20479118 XCR1 constitutes the first conserved specific marker for cell subsets homologous to mouse CD8alpha+ dendritic cells in higher vertebrates.
20479115 CD141+ dendritic cells are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 by Ca2+ mobilization and potent chemotaxis.
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AA Sequence

MESSGNPESTTFFYYDLQSQPCENQAWVFATLATTVLYCLVFLLSLVGNSLVLWVLVKYESLESLTNIFI      1 - 70
LNLCLSDLVFACLLPVWISPYHWGWVLGDFLCKLLNMIFSISLYSSIFFLTIMTIHRYLSVVSPLSTLRV     71 - 140
PTLRCRVLVTMAVWVASILSSILDTIFHKVLSSGCDYSELTWYLTSVYQHNLFFLLSLGIILFCYVEILR    141 - 210
TLFRSRSKRRHRTVKLIFAIVVAYFLSWGPYNFTLFLQTLFRTQIIRSCEAKQQLEYALLICRNLAFSHC    211 - 280
CFNPVLYVFVGVKFRTHLKHVLRQFWFCRLQAPSPASIPHSPGAFAYEGASFY                     281 - 333
//

Text Mined References (26)

PMID Year Title
26966045 2016 Comparative genomics analysis of mononuclear phagocyte subsets confirms homology between lymphoid tissue-resident and dermal XCR1(+) DCs in mouse and human and distinguishes them from Langerhans cells.
26166822 2015 XCR1 promotes cell growth and migration and is correlated with bone metastasis in non-small cell lung cancer.
25520399 2015 Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.
22964431 2012 The lymphotactin receptor is expressed in epithelial ovarian carcinoma and contributes to cell migration and proliferation.
21948982 2011 Cutting edge: expression of XCR1 defines mouse lymphoid-tissue resident and migratory dendritic cells of the CD8?+ type.
21514207 2011 Genetic variation in ?-synuclein kinases (CK-2? and GRK-5) and risk of Parkinson's disease.
21411777 2011 XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow.
20541533 2010 Conservation of a chemokine system, XCR1 and its ligand, XCL1, between human and mice.
20479118 2010 The XC chemokine receptor 1 is a conserved selective marker of mammalian cells homologous to mouse CD8alpha+ dendritic cells.
20479115 2010 Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells.
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