| Tbio | Chromobox protein homolog 5 |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 125 |
| Grant Count | 28 |
| R01 Count | 13 |
| Funding | $3,026,131.65 |
| PubMed Score | 80.61 |
| PubTator Score | 390.76 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | 1.300 | 0.011 |
| astrocytic glioma | 1.100 | 0.049 |
| ependymoma | 1.800 | 0.000 |
| oligodendroglioma | 1.800 | 0.010 |
| permanent atrial fibrillation | -1.200 | 0.015 |
| osteosarcoma | 2.065 | 0.000 |
| atypical teratoid / rhabdoid tumor | 2.200 | 0.000 |
| glioblastoma | 1.500 | 0.000 |
| group 3 medulloblastoma | 1.400 | 0.001 |
| medulloblastoma, large-cell | 2.000 | 0.000 |
| primitive neuroectodermal tumor | 1.700 | 0.000 |
| adrenocortical carcinoma | 1.378 | 0.001 |
| sarcoidosis | 1.200 | 0.019 |
| cystic fibrosis | -1.100 | 0.005 |
| pediatric high grade glioma | 1.200 | 0.001 |
| acute myeloid leukemia | 1.400 | 0.015 |
| lung adenocarcinoma | 1.100 | 0.000 |
| lung carcinoma | 1.100 | 0.000 |
| Alzheimer's disease | 1.100 | 0.043 |
| Pick disease | 1.600 | 0.000 |
| ovarian cancer | 2.000 | 0.000 |
| PMID | Text |
|---|---|
| 26791953 | We demonstrate that an hnRNPA1 and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells |
| 26157143 | PIP5K1A modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha. |
| 25960296 | Identify a nuclear localization signal within the 462-494 amino acid region of TRIM28 that overlaps with its HP1 binding site. GST-pulldown experiments revealed the interaction of the arginine-rich TRIM28 NLS with various importin alpha subtypes. |
| 25945750 | Jra recruits the HP1a/KDM4A complex to its gene body region upon osmotic stress to reduce H3K36 methylation levels and disrupt H3K36 methylation-dependent histone deacetylation |
| 25934638 | a considerable number of alternative splicing events could have a chromatin-dependent regulation involving the association of HP1alpha and CTCF near regulated exons. |
| 25818296 | SET interacts with the Kruppel-associated box (KRAB)-associated co-repressor KAP1, and its overexpression results in the sustained retention of KAP1 and Heterochromatin protein 1 (HP1) on chromatin |
| 25704815 | HP1 regulates this gene's alternative splicing in a methylation-dependent manner by recruiting splicing factors to its methylated form. |
| 25588582 | HP1alpha plays an important role in the differentiation and angiogenic function of Endothelial Progenitor Cells. |
| 25519718 | Paternal heterochromatin formation in human embryos is H3K9/HP1 directed and primed by sperm-derived histone modifications. |
| 25384975 | RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27107012 | 2016 | Pooled-matrix protein interaction screens using Barcode Fusion Genetics. |
| 26791953 | 2016 | Regulatory dissection of the CBX5 and hnRNPA1 bi-directional promoter in human breast cancer cells reveals novel transcript variants differentially associated with HP1? down-regulation in metastatic cells. |
| 26157143 | 2015 | Phosphatidylinositol-4-phosphate 5-Kinase 1? Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-?. |
| 25960296 | 2015 | Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box. |
| 25945750 | 2015 | HP1a/KDM4A is involved in the autoregulatory loop of the oncogene gene c-Jun. |
| 25934638 | 2015 | A chromatin code for alternative splicing involving a putative association between CTCF and HP1? proteins. |
| 25818296 | 2015 | The nuclear oncogene SET controls DNA repair by KAP1 and HP1 retention to chromatin. |
| 25772364 | 2015 | SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage. |
| 25755297 | 2015 | System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. |
| 25704815 | 2015 | HP1 is involved in regulating the global impact of DNA methylation on alternative splicing. |
| More... |
