| Tbio | Chromobox protein homolog 5 |
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 6.3e-21 |
| lung adenocarcinoma | 2716 | 1.3e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.8e-06 |
| Pick disease | 1894 | 3.5e-05 |
| medulloblastoma, large-cell | 6241 | 5.5e-05 |
| ovarian cancer | 8519 | 8.5e-05 |
| glioblastoma | 5792 | 3.3e-04 |
| primitive neuroectodermal tumor | 3035 | 4.1e-04 |
| pediatric high grade glioma | 1064 | 1.4e-03 |
| adrenocortical carcinoma | 1428 | 3.7e-03 |
| oligodendroglioma | 2850 | 3.9e-03 |
| cystic fibrosis | 1695 | 4.9e-03 |
| Rheumatoid arthritis | 1191 | 1.1e-02 |
| osteosarcoma | 7950 | 1.5e-02 |
| permanent atrial fibrillation | 45 | 1.5e-02 |
| acute myeloid leukemia | 783 | 1.5e-02 |
| ependymoma | 4679 | 1.8e-02 |
| sarcoidosis | 370 | 1.9e-02 |
| Alzheimer's disease | 658 | 4.3e-02 |
| group 3 medulloblastoma | 4104 | 4.3e-02 |
| astrocytic glioma | 2597 | 4.9e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.400 | 1.5e-02 |
| adrenocortical carcinoma | 1.309 | 3.7e-03 |
| Alzheimer's disease | 1.100 | 4.3e-02 |
| astrocytic glioma | 1.100 | 4.9e-02 |
| atypical teratoid / rhabdoid tumor | 2.200 | 4.8e-06 |
| cystic fibrosis | -1.100 | 4.9e-03 |
| ependymoma | 1.100 | 1.8e-02 |
| glioblastoma | 1.500 | 3.3e-04 |
| group 3 medulloblastoma | 1.200 | 4.3e-02 |
| lung adenocarcinoma | 1.100 | 1.3e-06 |
| lung carcinoma | 1.100 | 6.3e-21 |
| medulloblastoma, large-cell | 1.500 | 5.5e-05 |
| oligodendroglioma | 1.700 | 3.9e-03 |
| osteosarcoma | 1.349 | 1.5e-02 |
| ovarian cancer | -1.400 | 8.5e-05 |
| pediatric high grade glioma | 1.200 | 1.4e-03 |
| permanent atrial fibrillation | -1.200 | 1.5e-02 |
| Pick disease | 1.600 | 3.5e-05 |
| primitive neuroectodermal tumor | 1.700 | 4.1e-04 |
| Rheumatoid arthritis | 1.300 | 1.1e-02 |
| sarcoidosis | 1.200 | 1.9e-02 |
