Tchem | Collagenase 3 |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 1.92858707392468E-7 |
lung adenocarcinoma | 2714 | 4.57147162876755E-6 |
Breast cancer | 3099 | 5.42013229839002E-5 |
head and neck cancer and chronic obstructive pulmonary disease | 237 | 0.0121503675267005 |
head and neck cancer | 270 | 0.0214735125923913 |
invasive ductal carcinoma | 2950 | 0.0326614667580019 |
colon cancer | 1475 | 0.0405259190814104 |
cutaneous lupus erythematosus | 1056 | 0.0463542327961706 |
Disease | Target Count |
---|---|
Metaphyseal anadysplasia 1 | 1 |
Spondyloepimetaphyseal dysplasia Missouri type | 1 |
Disease | log2 FC | p |
---|---|---|
cutaneous lupus erythematosus | 1.700 | 0.046 |
periodontitis | 1.100 | 0.000 |
non-small cell lung cancer | 1.825 | 0.000 |
colon cancer | 1.100 | 0.041 |
lung adenocarcinoma | 1.700 | 0.000 |
invasive ductal carcinoma | 1.222 | 0.033 |
Breast cancer | 1.500 | 0.000 |
head and neck cancer | 1.300 | 0.021 |
head and neck cancer and chronic obstruc... | 1.300 | 0.012 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Platypus | OMA EggNOG |
Chicken | OMA Inparanoid |
Anole lizard | OMA Inparanoid |
Xenopus | OMA Inparanoid |
CHEMBL250503
pIC50 6.00
CHEMBL1940299
pIC50 6.00
CHEMBL319055
pIC50 6.00
CHEMBL584559
pIC50 6.01
CHEMBL311768
pIC50 6.01
CHEMBL250710
pIC50 6.02
CHEMBL70207
pIC50 6.02
CHEMBL185279
pKi 6.02
CHEMBL19179
pIC50 6.02
CHEMBL496423
pIC50 6.03
CHEMBL579067
pIC50 6.03
CHEMBL1784339
pIC50 6.03
CHEMBL3358155
pIC50 6.03
CHEMBL3675599
pKi 6.03
CHEMBL181022
pKi 6.03
CHEMBL276275
pIC50 6.04
CHEMBL329043
pKi 6.04
CHEMBL473326
pIC50 6.04
CHEMBL3350685
pIC50 6.05
CHEMBL3675545
pKi 6.05
AID | Type | Active / Inconclusive / Inactive | Description |
---|---|---|---|
570 | screening |
46 / 0 / 64879 | Primary biochemical high-throughput screening assay for inhibitors of Matrix Metalloproteinase 13 (MMP13) activity |
734 | screening |
8 / 0 / 5141 | Assay to identify inhibitors among the possible fluorescent artifacts from the primary HTS inhibition assay of Matrix Metalloproteinase 13 (MMP13) activity |
735 | confirmatory |
15 / 0 / 27 | Dose-response biochemical assay for inhibitors of Matrix Metalloproteinase 13 (MMP13) activity |
769 | confirmatory |
4 / 0 / 4 | Dose response biochemical assay for autofluorescent inhibitors of Matrix Metalloproteinase 13 (MMP13) activity |
1931 | summary |
2 / 0 / 0 | Summary of probe development efforts to identify inhibitors of Matrix Metalloproteinase-13 (MMP-13) |
2067 | screening |
9 / 0 / 0 | Late stage results from the probe development efforts to identify inhibitors of Matrix Metalloproteinase-13 (MMP-13). |
PMID | Text |
---|---|
26934732 | Hyaluronic acid exhibits a pronounced suppressive effect on MMP-13 expression in osteoarthritis. |
26474296 | IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade. |
26447617 | Report modified platelet deposition on matrix metalloproteinase 13 digested collagen I |
26395178 | Data show that the expression of transforming growth factor beta 1 (TGFB1) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3) and matrix metalloproteinase-13 (MMP13) in osteoarthritis (OA)-affected cartilage. |
26378022 | GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. |
26369384 | SENP2 inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1/TBLR1, which inhibits nuclear translocation of beta-catenin. |
26362844 | siRNA inhibited the effect of MMP13-containing exosomes on tumor cells metastasis as well as angiogenesis |
26308852 | RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13 |
26305549 | Data show that blocking the interleukin-8 (IL-8)/androgen receptor (AR)/matrix metalloproteinases (MMPs) signals partially reversed the infiltrating B cells capacity to increase the bladder cancer (BCa) cell invasion. |
26305372 | together, these data demonstrate that SERPINE2 might prevent cartilage catabolism by inhibiting the expression of MMP-13, one of the most relevant collagenases, involved in cartilage breakdown in OA. |
More... |
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLRE 1 - 70 MQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKK 71 - 140 AFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSS 141 - 210 SKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKT 211 - 280 PDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFR 281 - 350 GRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI 351 - 420 EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 421 - 471 //
PMID | Year | Title |
---|---|---|
26934732 | 2016 | Hyaluronic Acid Suppresses the Expression of Metalloproteinases in Osteoarthritic Cartilage Stimulated Simultaneously by Interleukin 1? and Mechanical Load. |
26474296 | 2015 | Interleukin-1 Receptor Antagonist Has a Novel Function in the Regulation of Matrix Metalloproteinase-13 Expression. |
26447617 | 2015 | Modified platelet deposition on matrix metalloproteinase 13 digested collagen I. |
26395178 | 2015 | Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-? signalling pathway. |
26378022 | 2015 | Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion. |
26369384 | 2015 | SENP2 regulates MMP13 expression in a bladder cancer cell line through SUMOylation of TBL1/TBLR1. |
26362844 | 2015 | Matrix metalloproteinase 13-containing exosomes promote nasopharyngeal carcinoma metastasis. |
26308852 | 2015 | RKIP Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13. |
26305549 | 2015 | Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals. |
26305372 | 2015 | SERPINE2 Inhibits IL-1?-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-?B/AP-1 Pathways. |
More... |