| Tchem | Collagenase 3 |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Comments
Property Summary
| Ligand Count | 2,029 |
| NCBI Gene PubMed Count | 287 |
| PubMed Score | 1243.82 |
| PubTator Score | 649.81 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Craniofacial Abnormalities | 151 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Metaphyseal chondrodysplasia Spahr type | 1 | 0.0 | 0.0 |
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Spondyloepimetaphyseal Dysplasia, Missouri Type | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| periodontitis | 293 | 4.0e-10 |
| non-small cell lung cancer | 2890 | 1.9e-07 |
| Breast cancer | 3578 | 5.4e-05 |
| lung adenocarcinoma | 2716 | 5.8e-05 |
| head and neck cancer and chronic obstructive pulmonary disease | 239 | 1.2e-02 |
| head and neck cancer | 271 | 2.1e-02 |
| invasive ductal carcinoma | 2951 | 3.3e-02 |
| colon cancer | 1478 | 4.1e-02 |
| cutaneous lupus erythematosus | 1057 | 4.6e-02 |
| Disease | Target Count |
|---|---|
| Metaphyseal Dysplasia, Spahr Type | 1 |
| Metaphyseal anadysplasia | 2 |
| Disease | log2 FC | p |
|---|---|---|
| periodontitis | 1.100 | 4.0e-10 |
| Breast cancer | 1.500 | 5.4e-05 |
| colon cancer | 1.100 | 4.1e-02 |
| cutaneous lupus erythematosus | 1.700 | 4.6e-02 |
| head and neck cancer | 1.300 | 2.1e-02 |
| head and neck cancer and chronic obstruc... | 1.300 | 1.2e-02 |
| invasive ductal carcinoma | 1.222 | 3.3e-02 |
| lung adenocarcinoma | 1.500 | 5.8e-05 |
| non-small cell lung cancer | 1.825 | 1.9e-07 |
CHEMBL250503
pIC50 6.00
CHEMBL1940299
pIC50 6.00
CHEMBL319055
pIC50 6.00
CHEMBL584559
pIC50 6.01
CHEMBL311768
pIC50 6.01
CHEMBL250710
pIC50 6.02
CHEMBL70207
pIC50 6.02
CHEMBL185279
pKi 6.02
CHEMBL19179
pIC50 6.02
CHEMBL496423
pIC50 6.03
CHEMBL579067
pIC50 6.03
CHEMBL1784339
pIC50 6.03
CHEMBL3358155
pIC50 6.03
CHEMBL3675599
pKi 6.03
CHEMBL181022
pKi 6.03
CHEMBL276275
pIC50 6.04
CHEMBL329043
pKi 6.04
CHEMBL473326
pIC50 6.04
CHEMBL3350685
pIC50 6.05
CHEMBL3675545
pKi 6.05
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLRE 1 - 70 MQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKK 71 - 140 AFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSS 141 - 210 SKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKT 211 - 280 PDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFR 281 - 350 GRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI 351 - 420 EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 421 - 471 //
