Tclin CHRNA4 Neuronal acetylcholine receptor subunit alpha-4

Protein Summary

Description

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• P43681
• Q4JGR7
• Q4VAQ5
• Q4VAQ6

Gene Name

• CHRNA4

Ensembl ID

• ENST00000370263
• ENSP00000359285
• ENSG00000101204
• ENST00000615287
• ENSP00000483388

Symbol

• NACRA4
• EBN
• BFNC
• EBN1
• NACHR
• NACRA4
• NACHRA4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.96
molecular function	0.96
drug	0.89
protein domain	0.85
biological process	0.71

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-4

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-4

Protein / Receptor / Ligand-gated Ion Channel / Acetylcholine Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-4

Protein / Receptor / Ligand-gated Ion Channel / Gaba Receptor / Neuronal Acetylcholine Receptor Subunit Alpha-4

DTO Classes

Protein / Ion Channel / Neurotransmitter Receptor, Cys Loop, Ligand-gated Ion Channel (Lic) Family / Acetylcholine Receptor Subfamily / Alpha-4/chrna4 Sub-subfamily / Neuronal Acetylcholine Receptor Subunit Alpha-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.03   (req: < 5)

Gene RIFs: 157   (req: <= 3)

Antibodies: 266   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.03   (req: >= 5)

Gene RIFs: 157   (req: > 3)

Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 87

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2