Tbio MAGEA12 Melanoma-associated antigen 12

Protein Summary

Description

Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. This gene is closely related to several other genes clustered on chromosome X. These genes may be overexpressed in tumors. Multiple alternatively spliced variants encoding the same protein have been identified. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• P43365
• Q6FHH8
• Q9NSD3

Gene Name

• MAGEA12

Ensembl ID

• ENST00000357916
• ENSP00000350592
• ENSG00000213401
• ENST00000393869
• ENSP00000377447
• ENST00000393900
• ENSP00000377478

Symbol

• MAGE12
• CT1.12
• MAGE12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.69
tissue sample	0.69
PubMedID	0.45
chemical	0.43
protein domain	0.41

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Melanoma-associated Antigen 12

DTO Classes

Protein / Cell Adhesion / Melanoma-associated Antigen 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.24   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0