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  5. Nuclear receptor subfamily 4 group A member 2

Tchem Nuclear receptor subfamily 4 group A member 2

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 8
NCBI Gene PubMed Count 159
PubMed Score 415.39
PubTator Score 263.74

Knowledge Summary

Patent (24,403)

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Disease Target Count Z-score Confidence
Parkinson's disease 392 6.178 3.1

Expression

  Differential Expression (35)

Disease log2 FC p
acute myeloid leukemia 2.100 2.2e-02
adrenocortical carcinoma -4.367 3.3e-10
adult high grade glioma -2.100 8.2e-03
astrocytoma -1.200 1.5e-09
atypical teratoid / rhabdoid tumor -2.200 1.5e-04
Barrett's esophagus 1.400 4.5e-02
Breast cancer 1.700 3.7e-02
chronic lymphosyte leukemia -1.500 7.2e-05
chronic rhinosinusitis -1.458 2.5e-02
ependymoma -2.200 1.3e-07
esophageal adenocarcinoma 1.100 3.6e-02
gastric cancer -1.500 3.6e-03
glioblastoma -2.300 3.5e-07
group 4 medulloblastoma -1.800 2.0e-02
hepatocellular carcinoma -2.800 3.2e-05
interstitial cystitis 1.300 4.4e-02
interstitial lung disease -2.600 3.4e-02
lung adenocarcinoma -1.242 9.1e-03
lung cancer -2.800 3.2e-04
medulloblastoma, large-cell -2.200 2.9e-03
nasopharyngeal carcinoma -1.200 2.6e-04
nephrosclerosis -1.020 6.0e-04
non-small cell lung cancer -2.634 2.0e-15
oligodendroglioma -1.300 5.2e-03
osteosarcoma 1.864 3.6e-02
pancreatic cancer -1.600 1.3e-03
pancreatic carcinoma -1.600 1.3e-03
pituitary cancer -4.800 5.3e-09
primitive neuroectodermal tumor -1.400 2.6e-02
psoriasis -2.500 6.3e-08
Rheumatoid arthritis 2.500 6.6e-03
tuberculosis -1.300 6.0e-04
ulcerative colitis 2.800 3.3e-05
urothelial carcinoma -1.700 4.6e-02
Waldenstrons macroglobulinemia 1.754 4.2e-02

Synonym

Accession P43354 Q16311 Q53RZ2 Q6NXU0
Symbols NOT
RNR1
HZF-3
NURR1
TINUR

Gene

NR4A2

PANTHER Protein Class (2)

PDB

1OVL  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (13)

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 GO Function (11)

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 GO Component (4)

 GO Process (27)

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 Compartment GO Term (24)

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 MGI Phenotype (9)

 GWAS Trait (3)

 HCA RNA Cell Line (55)

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Pathway (9)

Ligand (8)

Structure of CHEMBL246652

CHEMBL246652
pEC50 7.11

Structure of CHEMBL246654

CHEMBL246654
pEC50 7.23

Structure of CHEMBL393713

CHEMBL393713
pEC50 7.50

Structure of CHEMBL247879

CHEMBL247879
pEC50 7.59

Structure of CHEMBL399602

CHEMBL399602
pEC50 8.39

Structure of CHEMBL401032

CHEMBL401032
pEC50 8.41

Structure of CHEMBL399807

CHEMBL399807
pEC50 8.46

Structure of CHEMBL399603

CHEMBL399603
pEC50 9.10

Gene RIF (151)

AA Sequence 

MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSFSTFMDNYSTG      1 - 70
YDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSVYYKPSSPPTPTTPGFQVQHS     71 - 140
PMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQSPPGTPVSSCQMRFDGPLHVPMNPEPAGSH    141 - 210
HVVDGQTFAVPNPIRKPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTC    211 - 280
EGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK    281 - 350
SPQEPSPPSPPVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGW    351 - 420
AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFS    421 - 490
SNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLGKLP    491 - 560
ELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF                                    561 - 598
//

Text Mined References (161)

PMID Year Title