NR4A2
Nuclear receptor subfamily 4 group A member 2
Protein Summary
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000339562
- ENSP00000344479
- ENSG00000153234
- ENST00000409572
- ENSP00000386747
- ENST00000426264
- ENSP00000389986
- NOT
- NURR1
- TINUR
- NOT
- RNR1
- HZF-3
- NURR1
- TINUR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.99 | ||
molecular function | 0.97 | ||
PubMedID | 0.97 | ||
biological process | 0.95 | ||
transcription factor binding site profile | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 637.2 (req: < 5)
Gene RIFs: 166 (req: <= 3)
Antibodies: 372 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 637.2 (req: >= 5)
Gene RIFs: 166 (req: > 3)
Antibodies: 372 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 42
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0