You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
NR4A2
Nuclear receptor subfamily 4 group A member 2

Protein Summary
Description
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339562
  • ENSP00000344479
  • ENSG00000153234
  • ENST00000409572
  • ENSP00000386747
  • ENST00000426264
  • ENSP00000389986

Symbol
  • NOT
  • NURR1
  • TINUR
  • NOT
  • RNR1
  • HZF-3
  • NURR1
  • TINUR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.99
molecular function
0.97
PubMedID
0.97
biological process
0.95
transcription factor binding site profile
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.2   (req: < 5)
Gene RIFs: 166   (req: <= 3)
Antibodies: 372   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 637.2   (req: >= 5)
Gene RIFs: 166   (req: > 3)
Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0