Tclin GLP1R Glucagon-like peptide 1 receptor

Protein Summary

Description

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• P43220
• Q2M229
• Q99669
• GLP-1 receptor

Gene Name

• GLP1R

Ensembl ID

• ENST00000373256
• ENSP00000362353
• ENSG00000112164

Symbol

• GLP-1
• GLP-1R
• GLP-1-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
protein domain	0.85
disease perturbation	0.79
virus perturbation	0.64
small molecule perturbation	0.6

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class B Secretin Like / Glucagon Receptor / Glucagon-like Peptide 1 Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2044.36   (req: < 5)

Gene RIFs: 216   (req: <= 3)

Antibodies: 498   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2044.36   (req: >= 5)

Gene RIFs: 216   (req: > 3)

Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 455

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7