Tclin PTGER2 Prostaglandin E2 receptor EP2 subtype

Protein Summary

Description

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P43116
• D3DSC0
• Q52LG8
• PGE receptor EP2 subtype

Gene Name

• PTGER2

Ensembl ID

• ENST00000245457
• ENSP00000245457
• ENSG00000125384

Symbol

• EP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.87
PubMedID	0.84
gene perturbation	0.82
biological term	0.81
cell type or tissue	0.7

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostaglandin E2 Receptor Ep2 Subtype

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostaglandin E2 Receptor Ep2 Subtype

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.97   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 548   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.97   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 548   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 233

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8