Tclin PTGER3 Prostaglandin E2 receptor EP3 subtype

Protein Summary

Description

Receptor for prostaglandin E2 (PGE2) (PubMed:8307176, PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G(i) proteins, and to an elevation of intracellular calcium (PubMed:7883006, PubMed:8117308, PubMed:8135729, PubMed:7981210). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• P43115
• B0AZN4
• B1AK19
• B5BUP5
• O00326
• Q12943
• Q12944
• Q12945
• Q147X8
• Q16546
• Q5CZ59
• Q5CZ61
• Q5CZ62
• Q5CZ63
• Q5CZ64
• PGE receptor EP3 subtype

Gene Name

• PTGER3

Ensembl ID

• ENST00000306666
• ENSP00000302313
• ENSG00000050628
• ENST00000351052
• ENSP00000280208
• ENST00000356595
• ENSP00000349003
• ENST00000370924
• ENSP00000359962
• ENST00000370931
• ENSP00000359969
• ENST00000460330
• ENSP00000418073
• ENST00000479353
• ENSP00000421583
• ENST00000628037
• ENSP00000486617

Symbol

• EP3
• EP3e
• EP3-I
• EP3-II
• EP3-IV
• EP3-VI
• PGE2-R
• EP3-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
ligand (chemical)	0.97
disease perturbation	0.95
microRNA	0.87
protein domain	0.85

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Prostaglandin E2 Receptor Ep3 Subtype

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Prostaglandin E2 Receptor Ep3 Subtype

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.33   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 420   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.33   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 545

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5