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Tbio
NSG1
Neuronal vesicle trafficking-associated protein 1

Protein Summary
Description
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (PubMed:20599942, PubMed:20878061).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397958
  • ENSP00000381049
  • ENSG00000168824
  • ENST00000421177
  • ENSP00000388823
  • ENST00000433139
  • ENSP00000408833
  • ENST00000504171
  • ENSP00000425803
  • ENST00000505246
  • ENSP00000421841
  • ENST00000506380
  • ENSP00000425423
  • ENST00000513555
  • ENSP00000426358
  • ENST00000513829
  • ENSP00000425345
  • ENST00000621129
  • ENSP00000480081

Symbol
  • D4S234
  • NEEP21
  • P21
  • D4S234
  • NEEP21
  • D4S234E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor perturbation
0.68
PubMedID
0.58
microRNA
0.57
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0