Property Summary

NCBI Gene PubMed Count 348
PubMed Score 404.86
PubTator Score 972.00

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
non-small cell lung cancer 2798 1.9144844809716E-11
astrocytoma 1493 4.00666576222471E-9
Amyotrophic Lateral Sclerosis 432 2.18484942806117E-8
ulcerative colitis 2087 5.91568026521607E-7
pituitary cancer 1972 1.30565810072327E-6
acute quadriplegic myopathy 1157 2.81345260197309E-6
pilocytic astrocytoma 3086 6.19843447732021E-6
Breast cancer 3099 1.10054969522671E-5
oligodendroglioma 2849 1.2581051193119E-5
cystic fibrosis 1670 1.82074621795475E-5
adult high grade glioma 2148 4.47746380618465E-5
tuberculosis and treatment for 6 months 686 1.66255710509167E-4
hepatocellular carcinoma 550 5.70669187099413E-4
atypical teratoid / rhabdoid tumor 4369 0.0038481776104098
ovarian cancer 8492 0.0045112318078117
pancreatic cancer 2300 0.00894195173640709
invasive ductal carcinoma 2950 0.0105907220142016
subependymal giant cell astrocytoma 2287 0.0127878646783379
primary pancreatic ductal adenocarcinoma 1271 0.0131781435560755
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0138157400016371
glioblastoma 5572 0.022542938885212
ductal carcinoma in situ 1745 0.0237376413214643
nasopharyngeal carcinoma 1056 0.028048721499729
spina bifida 1064 0.0412572915265152
Disease Target Count Z-score Confidence
Glaucoma 135 3.255 1.6
Brain cancer 24 0.0 1.0
Malignant glioma 23 0.0 1.0
Disease Target Count Z-score Confidence
Cancer 2346 5.324 2.7



Accession P42772 O15125 Q6FI09
Symbols P15


  Ortholog (11)

Gene RIF (303)

27090891 Data indicate that Philadelphia chromosome-positive (Ph-positive) acute lymphoblastic leukemia (ALL) patients who presented with cyclin dependent kinase inhibitor 2A/B (CDKN2A/B) deletion showed a higher rate of CD20 antigen expression.
27060304 High expression of p15 antisense RNA is associated with acute myeloid leukemia.
27049325 Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2
26911146 Data show that KDM5B is frequently up-regulated in hepatocellular carcinoma tissues and cell lines and correlated with poor prognosis. Its depletion leads to highly impaired clonogenesis and cell cycle arrest through up-regulation of p15 and p27.
26868379 CDKN2B variants are associated with pediatric B-cell precursor acute lymphoblastic leukemia.
26782424 Inhibited HO-1 expression attenuated the hypermethylation of CDKN2B by suppressing DNMT1, which was conducive to treatment by cooperating with decitabine.
26596284 Loss of CDKN2B may not only promote cardiovascular disease through the development of atherosclerosis but may also impair TGFbeta signaling and hypoxic neovessel maturation.
26577493 The CDKN2A/CDKN2B rs4977756 polymorphism increases the risk of developing glioma in Caucasians. (Meta-analysis)
26501552 Children with ALL have higher levels of p15 CpG island methylation than a control group of children with ITP.
26470845 Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

AA Sequence


Text Mined References (348)

PMID Year Title
27090891 2016 Correlation between deletion of the CDKN2 gene and tyrosine kinase inhibitor resistance in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.
27060304 2016 [High expression of p15 antisense RNA is a frequent event in acute myeloid leukemia].
27049325 2016 Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study.
26911146 2016 Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27.
26868379 2016 A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.
26782424 2015 Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.
26596284 2016 CDKN2B Regulates TGF? Signaling and Smooth Muscle Cell Investment of Hypoxic Neovessels.
26577493 2016 Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants.
26501552 2016 Hypermethylation of p15 gene associated with an inferior poor long-term outcome in childhood acute lymphoblastic leukemia.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.