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Tbio
LRPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

Protein Summary
Description
May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260665
  • ENSP00000260665
  • ENSG00000138095

Symbol
  • LRP130
  • LSFC
  • GP130
  • LRP130
  • CLONE-23970
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.93
hub protein
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.54   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.54   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0