Tbio NCAPD3 Condensin-2 complex subunit D3

Protein Summary

Description

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959). Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P42695
• A6NFS2
• Q4KMQ9

Gene Name

• NCAPD3

Ensembl ID

• ENST00000534548
• ENSP00000433681
• ENSG00000151503

Symbol

• CAPD3
• KIAA0056
• CAPD3
• hcp-6
• CAP-D3
• MCPH22
• hHCP-6
• hCAP-D3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
transcription factor binding site profile	0.79
histone modification site profile	0.78
interacting protein	0.78
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Condensin-2 Complex Subunit D3

DTO Classes

Protein / Nucleic Acid Binding / Condensin-2 Complex Subunit D3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.3   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.3   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0