Tchem FRK Tyrosine-protein kinase FRK

Protein Summary

Description

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42685
• B4DY49
• Q13128
• Q9NTR5

Gene Name

• FRK

Ensembl ID

• ENST00000606080
• ENSP00000476145
• ENSG00000111816

Symbol

• PTK5
• RAK
• GTK
• RAK
• PTK5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
virus perturbation	0.76
gene perturbation	0.62
PubMedID	0.58

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Tyrosine-protein Kinase Frk

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.39   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 517   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.39   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 517   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 52

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5