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Tchem
ABL2
Tyrosine-protein kinase ABL2

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344730
  • ENSP00000339209
  • ENSG00000143322
  • ENST00000367623
  • ENSP00000356595
  • ENST00000392043
  • ENSP00000375897
  • ENST00000502732
  • ENSP00000427562
  • ENST00000504405
  • ENSP00000426831
  • ENST00000507173
  • ENSP00000423413
  • ENST00000511413
  • ENSP00000424697
  • ENST00000512653
  • ENSP00000423578

Symbol
  • ABLL
  • ARG
  • ARG
  • ABLL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
0.99
molecular function
0.99
protein domain
0.99
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.33   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.33   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5