Tchem | Tyrosine-protein kinase TXK |
Comments
Disease | Target Count | P-value |
---|---|---|
lung carcinoma | 2844 | 1.88652753228125E-20 |
malignant mesothelioma | 3163 | 1.13031037407698E-6 |
osteosarcoma | 7933 | 0.00211396210044785 |
Common variable immunodeficiency | 98 | 0.0211033204035696 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | -1.900 | 0.000 |
osteosarcoma | -1.760 | 0.002 |
Common variable immunodeficiency | -1.421 | 0.021 |
lung carcinoma | -1.500 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA Inparanoid |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
CHEMBL398422
pIC50 7.55
CHEMBL249097
pKd 8.00
CHEMBL3290142
pIC50 8.72
CHEMBL3290148
pIC50 8.85
CHEMBL249317
pIC50 9.40
PMID | Text |
---|---|
25593320 | These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK, and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo. |
20800603 | Observational study of gene-disease association. (HuGE Navigator) |
20628086 | Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
20379614 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) |
19913121 | Observational study of gene-disease association. (HuGE Navigator) |
18941202 | Itk and Txk exert their effects on T helper (Th) cell differentiation and function at the level of expression; transgenic Txk is not a specific regulator of Th1 responses. |
16809408 | Th1 cells expressing Txk and Th1-associated cytokines may play a critical role in the development of skin and intestinal lesions in patients with Behcet's disease. |
11859127 | fuctions as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription |
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRK 1 - 70 PLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTEN 71 - 140 KITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDS 141 - 210 GQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSG 211 - 280 QFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGC 281 - 350 LLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY 351 - 420 VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHL 421 - 490 APMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW 491 - 527 //
PMID | Year | Title |
---|---|---|
25593320 | 2015 | Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694. |
24728074 | 2014 | Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome. |
23128233 | 2012 | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. |
20800603 | 2010 | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. |
20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. |
20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
19913121 | 2009 | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
19290923 | 2009 | Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. |
18941202 | 2008 | Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. |
17344846 | 2007 | Patterns of somatic mutation in human cancer genomes. |
More... |